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Activity 1 Recall that wave summation occurs when a skeletal muscle is simulated with such frequency that muscle twitches overlap and result in astronger contraction than a single muscle twitch. When the stimulations are frequent enough , the muscle reaches astate of fused tetanus, during wich the individual muscle twitches cannot be distinguished. Tetanus occurs in skeletal muscle because skeletal muscle has a relatively short absolute refractory period (a period during which action potentials cannot be generated no matter how strong the stimulus) Unlike skeletal muscle, cardiac muscle has a relatively long refractory period and is thus incapable of wave summation. In fact, cardiac muscle muscle is incapable of reacting to any stimulus before approximately the middle of phrase 3, and will not respond to a normal cardiac stimulus before phrase 4. The period of time between the beginning of the cardiac action potential and the approximate middle of phrase 3 is the absolute refractory period. The period of time between the absolute refractory period and phrase 4 is the relative refractory period. The total refractory period of cardiac muscle is 200-250 milliseconds-almost as long as contraction of teh cardiac muscle.Activity 2 Sistem saraf otonom memiliki dua cabang: sistem saraf simpatik (figh atau penerbangan) dan saraf parasimpatik sistem (istirahat dan mencerna). beristirahat kedua sistem saraf simpatik dan parasympatethic bekerja tetapi cabang parasimpatis lebih aktif. Sistem saraf simpatik menjadi lebih aktif bila diperlukan, misalnya, selama latihan dan ketika menghadapi bahaya. Saraf vagus membawa sinyal ke jantung. Jika stimulasi saraf vagus (stimulasi vagal) berlebihan, jantung akan berhenti memukuli. setelah waktu yang singkat, ventrikel akan mulai untuk mengalahkan lagi. dimulainya detak jantung disebut sebagai vagal melarikan diri dan dapat menjadi hasil dari refleks simpatik atau initation irama oleh serat Purkinje. Sinoatrial node (SA node) adalah sekelompok autorhythmic sel-sel jantung yang ditemukan di atrium kanan dinding di hati manusia. SA node telah fartest tingkat depolarization spontan dan untuk alasan itu menentukan denyut jantung dan karena itu disebut sebagai dengan hati "alat"Kegiatan 3 Manusia homeothermic, yang berarti bahwa tubuh manusia mempertahankan suhu tubuh internal dalam 35,8-38,2 C berkisar meskipun temparature eksternal berubah. During extreme external temperature conditions , the body might not be able to maintain homeostatis and either hyperthermia (elevated body temperature) or hypothermia (low body temperature ) could result . in contrast, the frog is poikilothermic animal . its internal body temperature changes depending on the temperature of its external environment because it lacks internal homeostatic regulatory mechanismsActivity 4 The sympathetic nervous system is activated in times of “fight or flight “ and sympathetic nerve fiber release norephinephrine (also known as noradrenaline)and ephinephrine (also known as adrenaline ) at their cardiac synapses .Norephinephrine and ephinephrine insrease the frequency of action potentials by binding to B1 adrenergic receptors embedded in the plasma membrane of sinoatrial (SA) node (pacemaker)cellsParasympathetic nerve fibers release acetylcholine at their cardiac synapses .Chemical modifiers that inhibit , mimic, or enhance the action of acetylcholine in the body are labeled cholinergic. Chemical modifiers that inhibit , mimic, or enhance the action of ephineprine in the body are adrenergic . if the modifier works in the same fashion as the neurotransmitter (acethylcoline and norephineprine ) it is an agonist . if the modifier works in oppostion to the neurotransmitter it is an antagonist .Activity 5Modifiers that affect heart rate are chronotropic and modifiers that affect the force of contraction are inotropic .
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