Feline viral rhinotracheitis was a

Feline viral rhinotracheitis was a surprisingly severe disease in germfree
cats. The pathogenicity of FRV is apparently not dependent upon
the synergistic activity of the respiratory microbial flora. Clinically and
histologically, experimental feline rhinotracheitis in germfree cats was
similar to the disease in conventional cats.9 The ulcerative, fibrinopurulent
rhinitis in conventional cats had been attributed chiefly to the activity
of secondary bacterial invaders. In germfree cats, however, the virus
rapidly destroyed virtually all intranasal epithelium. The initial neutrophilic
inflammatory response which ensued was apparently elicited by
products of epithelial necrosis. To our knowledge the lesions produced
by FRV are the most severe of any viral disease reported thus far in
gernfree animals. By contrast, the respiratory and gastrointestinal lesions
which characterize viral diseases such as canine distemper and feline
infectious enteritis are completely absent in germfree animals.

Hasil (Bahasa Indonesia) 1:

Rhinotracheitis virus adalah penyakit yang sangat parah di germfreekucing. Pathogenicity FRV ini rupanya tidak bergantung padaaktivitas sinergis flora mikroba pernapasan. Klinis dansecara histologis, eksperimental kucing rhinotracheitis di germfree kucing adalahmirip dengan penyakit di konvensional cats.9 kolitis, fibrinopurulentrhinitis di konvensional kucing telah dikaitkan terutama untuk kegiatanpenyerbu bakteri sekunder. Dalam kucing germfree, namun, viruscepat menghancurkan hampir semua intranasal epitel. Awal prosesrespons radang yang terjadi ternyata menimbulkan olehproduk dari epitel nekrosis. Untuk pengetahuan kita lesi diproduksioleh FRV adalah yang paling parah dari penyakit virus yang dilaporkan sejauh ini digernfree hewan. Dengan kontras, pernafasan dan pencernaan lesiyang mengkarakterisasi virus penyakit seperti gigi taring dan kucingmenular radang usus sepenuhnya absen di germfree hewan.