Is Barrett's esophagus associated w

Is Barrett's esophagus associated with intestinal metaplasia of the gastric cardia?
Morales TG, et al. Am J Gastroenterol. 1997.
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Abstract
OBJECTIVE: Barrett's esophagus has been associated with adenocarcinoma of the esophagogastric junction and gastric cardia. The purpose of this study was to determine whether patients with Barrett's esophagus have a higher prevalence of intestinal metaplasia involving the gastric cardia than those without Barrett's esophagus.

METHODS: Two groups of patients were compared for the prevalence of intestinal metaplasia of the gastric cardia. Group 1 included 50 patients with well-defined Barrett's esophagus who were being followed in an endoscopic surveillance program. Group 2 consisted of 104 individuals participating in a separate study identifying the prevalence of cardia intestinal metaplasia in patients undergoing elective upper endoscopy. Both groups had biopsy specimens taken from the gastric cardia. Eleven patients in group 2 were found to have Barrett's esophagus and were excluded from the analysis. Histological evidence of intestinal metaplasia was defined as specialized columnar epithelium containing goblet cells staining with Alcian blue at pH 2.5.

RESULTS: The prevalence of cardia intestinal metaplasia in the 50 patients in group 1 (Barrett's esophagus) was 22%, whereas the prevalence in the 93 patients in group 2 (no Barrett's esophagus) was 24%, which was not a statistically significant difference. A significant difference between groups still could not be identified when the results were examined with regard to equal number of biopsy specimens taken. None of the patients in either group had dysplasia identified within the cardia intestinal metaplasia.

CONCLUSIONS: Patients with Barrett's esophagus do not have a higher prevalence of intestinal metaplasia of the gastric cardia than those presenting for routine endoscopy. Although intestinal metaplasia of the gastric cardia is a relatively common finding, dysplasia is uncommon. Therefore, we suggest that screening biopsy specimens of the gastric cardia in patients with Barrett's esophagus be limited to study protocols at this time. In addition, we believe that these data raise the question of whether a true association exists between Barrett's esophagus and gastric cardia cancer.

PMID 9382043 [PubMed - indexed for MEDLINE]

Hasil (Bahasa Indonesia) 1:

Is Barrett's esophagus associated with intestinal metaplasia of the gastric cardia?Morales TG, et al. Am J Gastroenterol. 1997.Show full citationAbstractOBJECTIVE: Barrett's esophagus has been associated with adenocarcinoma of the esophagogastric junction and gastric cardia. The purpose of this study was to determine whether patients with Barrett's esophagus have a higher prevalence of intestinal metaplasia involving the gastric cardia than those without Barrett's esophagus.METHODS: Two groups of patients were compared for the prevalence of intestinal metaplasia of the gastric cardia. Group 1 included 50 patients with well-defined Barrett's esophagus who were being followed in an endoscopic surveillance program. Group 2 consisted of 104 individuals participating in a separate study identifying the prevalence of cardia intestinal metaplasia in patients undergoing elective upper endoscopy. Both groups had biopsy specimens taken from the gastric cardia. Eleven patients in group 2 were found to have Barrett's esophagus and were excluded from the analysis. Histological evidence of intestinal metaplasia was defined as specialized columnar epithelium containing goblet cells staining with Alcian blue at pH 2.5.HASIL: Prevalensi Kardia usus metaplasia di 50 pasien dalam grup 1 (Barrett di kerongkongan) adalah 22%, sedangkan prevalensi di 93 pasien dalam grup 2 (tidak ada Barrett kerongkongan) adalah 24%, yang tidak perbedaan signifikan secara statistik. Perbedaan yang signifikan antara kelompok masih tidak dapat dikenali lagi ketika hasil diperiksa dalam jumlah yang sama spesimen biopsi yang diambil. Tak satu pun dari pasien dalam grup baik telah diidentifikasi dalam metaplasia usus Kardia Displasia.Kesimpulan: Pasien dengan kerongkongan Barrett's tidak memiliki prevalensi lebih tinggi dari usus metaplasia dari Kardia lambung daripada pemakalah Endoskopi rutin. Meskipun usus metaplasia dari Kardia lambung adalah sebuah temuan yang relatif umum, Displasia ini biasa. Oleh karena itu, kami menyarankan bahwa skrining spesimen biopsi dari Kardia lambung pada pasien dengan kerongkongan Barrett's menjadi terbatas untuk mempelajari protokol saat ini. Selain itu, kami percaya bahwa data ini meningkatkan pertanyaan tentang apakah sebuah asosiasi yang benar ada antara Barrett di kerongkongan dan kanker lambung Kardia.Kesalahan 9382043 [PubMed - diindeks untuk MEDLINE]