Results: We report that the P. guaj

Results: We report that the P. guajava extract
exerted anti-cancer control on both haematological
and solid neoplasias. P. guajava extract’s antitumour
properties were found to be tightly bound to
induction of apoptosis and differentiation. Use of ex
vivo myeloid leukaemia blasts corroborated that
P. guajava was able to induce cell death but did not
exhibit anti-cancer effects on all malignant cells
investigated, indicating selective activity against certain
types of tumour. Analyses of P. guajava pulp,
peel and seeds identified the pulp as being the most
relevant component for causing cell cycle arrest and
apoptosis, whereas peel was responsible for causing
cell differentiation. P. guajava itself and its pulpderived
extract were found to induce apoptosis accompanied by caspase activation and p16, p21,
Fas ligand (FASL TNF super-family, member 6),
Bcl-2-associated agonist of cell death (BAD) and
tumour necrosis factor receptor super-family, member
10b (DR5), overexpression.
Conclusions: Our findings showed that P. guajava
L. extract was able to exert anti-cancer activity on
cultures in vitro and ex vivo, supporting the hypothesis
of its anti malignant pro-apoptotic modulation.

Hasil (Bahasa Indonesia) 2:

Hasil: Kami melaporkan bahwa ekstrak guajava P.
diberikan kendali anti-kanker pada kedua hematologis
neoplasias dan padat. Antitumor P. guajava ekstrak itu
sifat yang ditemukan terikat erat dengan
induksi apoptosis dan diferensiasi. Penggunaan ex
vivo myeloid leukemia ledakan menguatkan bahwa
P. guajava mampu menginduksi kematian sel, tetapi tidak
menunjukkan efek anti-kanker pada semua sel ganas
diselidiki, yang menunjukkan aktivitas selektif terhadap beberapa
jenis tumor. Analisis P. guajava pulp,
kulit dan biji diidentifikasi pulp sebagai yang paling
komponen yang relevan untuk menyebabkan penangkapan siklus sel dan
apoptosis, sedangkan kulit bertanggung jawab untuk menyebabkan
diferensiasi sel. P. guajava sendiri dan pulpderived yang
ekstrak ditemukan untuk menginduksi apoptosis disertai dengan aktivasi caspase dan p16, p21,
Fas ligand (FasL TNF super-keluarga, anggota 6),
agonis Bcl-2 terkait kematian sel (BAD) dan
tumor necrosis reseptor faktor super-keluarga, anggota
10b (DR5), berlebih.
Kesimpulan: Temuan kami menunjukkan bahwa P. guajava
L. Ekstrak mampu mengerahkan aktivitas anti-kanker pada
budaya in vitro dan ex vivo, mendukung hipotesis
ganas modulasi anti pro-apoptosis nya.