the physicochemical properties of t

the physicochemical properties of the chemical leads

and has focused mainly on optimization of the in vitro

activity [1–3]. The rate at which a drug goes into the

solution when it is dissolved in an acidic or a basic

medium is proportional to the solubility of the drug.

Many drugs have different solubilities at different pHs.

These pH-dependent solubility differences lead to pH-

-dependent dissolution profiles. The solubility-pH pro-
file of drugs or amines has already been reported by

many authors [4–13].

The Henderson-Hasselbalch (HH) equation [14]

has been used many times for the mathematical des-
cription of the solubility-pH profile of drugs or amines

existing in the solution as a monomer [4,6,7].

Aqueous solubility has an essential role in the

bioavailability of oral drug formulations. There is an

established classification, namely, the biopharma-
ceutical classification system (BCS), which divides

drugs into four classes in terms of their solubility and

permeability [15]. The BCS classification correlates

the in vitro solubility and permeability to the in vivo

bioavailability.

In recent years, the problem of drug solubility in

water has become more acute and more common as

pharmaceutical companies have improved drugs for

certain therapeutic areas [16]. The accuracy of many

Hasil (Bahasa Indonesia) 1:

sifat kimia secara fisikokimia mengarah dan telah difokuskan terutama pada optimalisasi secara in vitroaktivitas [1 – 3]. Tingkat di mana obat yang masuk ke solusi ketika terlarut dalam asam atau dasar Media sebanding kelarutan obat. Banyak obat yang memiliki solubilities berbeda berbeda pHs. Perbedaan-perbedaan ini bergantung pada pH kelarutan menyebabkan pH- -Profil tergantung pembubaran. Kelarutan-pH pro-file dari obat-obatan atau amina telah dilaporkan oleh banyak penulis [4-13]. Persamaan Henderson-Hasselbalch (HH) [14] telah digunakan berkali-kali untuk des matematikacription kelarutan-pH profil obat-obatan atau amina ada solusi sebagai monomer [4,6,7]. Kelarutan berair memiliki peran penting dalam ketersediaanhayati formulasi obat oral. Ada didirikan klasifikasi, yaitu, biopharma-sistem klasifikasi ceutical (BCS), yang membagi obat-obatan ke dalam empat kelas dalam hal kelarutan mereka dan permeabilitas [15]. BCS klasifikasi berkorelasi Kelarutan secara in vitro dan permeabilitas di vivoketersediaanhayati. Dalam beberapa tahun terakhir, masalah narkoba kelarutan dalam air telah menjadi lebih akut dan lebih umum seperti perusahaan farmasi telah meningkatkan obat untuk terapeutik wilayah tertentu [16]. Keakuratan dari banyak