Therefore, the formulation of MA as

Therefore, the formulation of MA as sustained
release dosage form matrix tablets could be an alternative
ABSTRACT
Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It has a
dose of 250 mg 4 times daily. It has a very short half life of 2 hours and thus controlling the release would be
beneficial. In the present study, mefenamic acid 250 mg controlled release matrices were prepared by direct
compression and in-vitro drug dissolution studies were performed to find out the drug release rate and patterns.
Ethyl cellulose (EC), polyvinyl acetate (PVA) and their combination were used as rate controlling polymers. Effects
of addition of ethyl cellulose and polyvinyl acetate on in-vitro drug dissolution were studied. Tablets were
formulated using total polymer content as 20, 30 and 40 percent. In-vitro drug release was carried out using USP
Type II at 50 rpm in 900 ml of acidic dissolution medium (pH 1.2) for 2 hours, followed by 900 ml alkaline
dissolution medium (pH 7.4) up to 24 hours. Mean dissolution time is used to characterize drug release rate from a
dosage form and indicates the drug release retarding efficiency of polymer. When ethyl cellulose and polyvinyl
acetate were used alone as the only retarding polymer, retardation effect increased proportionately as the
concentration of polymer increased; however lacked the uniform release profile and desirable physical properties.
Combination in the matrix gave both the uniform retardation effect as well as desired physical properties to the
formulation. Several kinetic models were applied to the dissolution profiles to determine the drug release kinetics.
KEYWORDS: Mefenamic acid , Ethyl cellulose, Polyvinyl Acetate, Release Kinetics.
Ashtamkar Joel, et al. Journal of Biomedical and Pharmaceutical Research 2 (3) 2013, 130-134

approach to overcome the potential problems in the
gastrointestinal tract, in addition to minimizing dosing
frequency6, 7.
The present study is aimed at formulating
sustained release matrix tablets of mefenamic acid using
hydrophobic polymers viz. ethyl cellulose and polyvinyl
acetate.

Hasil (Bahasa Indonesia) 2:

Oleh karena itu, rumusan MA sebagai berkelanjutan
rilis tablet bentuk sediaan matriks bisa menjadi alternatif
ABSTRAK
Asam mefenamat adalah non-steroid obat anti-inflamasi yang digunakan untuk mengobati nyeri, termasuk nyeri haid. Ia memiliki
dosis 250 mg 4 kali sehari. Ia memiliki waktu paruh yang sangat singkat 2 jam dan dengan demikian mengendalikan rilis akan
menguntungkan. Dalam penelitian ini, mefenamat asam 250 mg dikendalikan matriks rilis disusun oleh langsung
kompresi dan in-vitro studi disolusi obat dilakukan untuk mengetahui tingkat pelepasan obat dan pola.
Etil selulosa (EC), polivinil asetat (PVA) dan kombinasinya digunakan sebagai polimer tingkat pengendalian. Efek
dari penambahan etil selulosa dan polivinil asetat pada in-vitro pembubaran obat dipelajari. Tablet yang
diformulasikan dengan menggunakan total kandungan polimer sebagai 20, 30 dan 40 persen. In-vitro pelepasan obat dilakukan dengan menggunakan USP
tipe II pada 50 rpm di 900 ml pembubaran media asam (pH 1,2) selama 2 jam, diikuti oleh 900 ml alkali
medium disolusi (pH 7,4) hingga 24 jam. Waktu pembubaran berarti digunakan untuk mengkarakterisasi tingkat pelepasan obat dari
bentuk sediaan dan menunjukkan pelepasan obat penghambat efisiensi polimer. Ketika etil selulosa dan polyvinyl
asetat digunakan sendiri sebagai satu-satunya polimer perlambatan, efek keterbelakangan meningkat secara proporsional sebagai
konsentrasi polimer meningkat; Namun kekurangan profil rilis seragam dan sifat fisik yang diinginkan.
Kombinasi dalam matriks memberi kedua efek keterbelakangan seragam serta sifat fisik yang diinginkan ke
formulasi. Beberapa model kinetik yang diterapkan pada profil disolusi untuk menentukan kinetika pelepasan obat.
KATA KUNCI: Asam mefenamat, Etil selulosa, Polyvinyl Acetate, Rilis Kinetics.
Ashtamkar Joel, et al. Journal of Biomedical dan Pharmaceutical Research 2 (3) 2013, 130-134 pendekatan untuk mengatasi potensi masalah di saluran pencernaan, selain meminimalkan dosis frequency6, 7. Penelitian ini bertujuan untuk merumuskan tablet rilis matriks berkelanjutan asam mefenamat menggunakan polimer hidrofobik yaitu. etil selulosa dan polyvinyl asetat.