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S. Typhi organisms are thought to invade thebody through the gut mucosa in the terminal ileum, possiblythrough specialized antigen-sampling cells known as M cells thatoverlie gut-associated lymphoid tissues, through enterocytes, orvia a paracellular route. S. Typhi crosses the intestinal mucosalbarrier after attachment to the microvilli by an intricate mechanisminvolving membrane ruffl ing, actin rearrangement, andinternalization in an intracellular vacuole. In contrast to nontyphoidalSalmonella , S. Typhi expresses virulence factors thatallow it to downregulate the pathogen recognition receptor –mediated host infl ammatory response. Within the Peyer patchesin the terminal ileum,
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