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Core tip: Nephrotic syndrome (NS) is the most com-mon pediatric glomerular disease. Although outcomesare favorable, the treatment of complicated nephroticsyndrome can be challenging. Rituximab (RTX) offersa safe and effective alternative to current immunosup-pressive therapies for complicated cases of NS. Thebest outcomes are seen in patients with steroid-dependent NS who have failed to respond to multiple therapies. However, the benefits of RTX therapy are limitedin patients with steroid-resistant nephrotic syndrome.Successful RTX therapy induces prolonged remissionand enables discontinuation of other medications with-out increasing the risk of infection and other adverseevents.
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