LICORICE (GLYCYRRHIZA GLABRA)Licori

LICORICE (GLYCYRRHIZA GLABRA)

Licorice extract is a common ingredient in many multicomponent dietary sup- plements. When ingested, the sweet tasting glycoside found in licorice, glycyrrhizin, is hydrolyzed by bacterial -glucuronidases in the intestine to yield the aglycone, glycyrrhetic acid.118 As a potent inhibitor of 11--hydroxysteroid dehydrogenase, glycyrrhetic acid increases access of cortisol to the mineralocorticoid receptor caus- ing sodium retention and potassium depletion.118,119 Accordingly, chronic ingestion of licorice extract may interfere with various medications, including antihyperten- sives and antiarrhythmic agents. Unlike many other phytochemicals, the pharmaco- kinetics of glycyrrhetic acid is well characterized.120 Its absorption is slow and formulation dependent. Circulating plasma concentrations of glycyrrhetic acid can range from 100 to 2000 nM—levels capable of inhibiting 11--hydroxysteroid dehydrogenase.118 In the liver, glycyrrhetic acid is conjugated and eliminated via biliary secretion, and subject to enterohepatic cycling120; therefore, liver dysfunction may exacerbate the onset and severity of mineralocorticoid side effects. Few pro- spective studies have examined licorice’s effect on drug pharmacokinetics. In one such study, inhibition of 11--hydroxysteroid dehydrogenase was the suspected

cause of decreased prednisolone clearance among healthy volunteers.121 As with many dietary supplements, there is large intersubject variability with regard to glycyrrhetic acid absorption, elimination, toxicity, and interaction potential, much of which is likely related to product quality and pattern of usage.118,122,123

Hasil (Bahasa Indonesia) 1:

LICORICE (GLYCYRRHIZA GLABRA)Ekstrak licorice adalah bahan umum dalam banyak multicomponent Diet sup-plements. Ketika ditelan, manis mencicipi glikosida ditemukan di licorice, glycyrrhizin, dihidrolisis oleh -glucuronidases bakteri dalam usus untuk menghasilkan aglycone, glycyrrhetic acid.118 sebagai inhibitor poten dehidrogenase 11--hydroxysteroid, asam glycyrrhetic meningkatkan akses kortisol untuk mineralocorticoid reseptor caus-ing natrium retensi dan kalium depletion.118,119 sesuai, kronis konsumsi ekstrak licorice dapat mengganggu berbagai obat-obatan , termasuk antihyperten-sives dan antiarrhythmic agen. Tidak seperti banyak phytochemical, pharmaco-kinetika asam glycyrrhetic baik characterized.120 penyerapan lambat dan perumusan tergantung. Beredar konsentrasi plasma asam glycyrrhetic dapat berkisar dari 100 sampai 2000 nM-tingkat mampu menghambat 11--hydroxysteroid dehydrogenase.118 dalam hati, glycyrrhetic asam conjugated dan dihilangkan melalui sekresi empedu, dan enterohepatic cycling120; oleh karena itu, disfungsi hati dapat memperburuk onset dan tingkat keparahan efek samping mineralocorticoid. Beberapa studi pro-spective telah memeriksa licorice yang berpengaruh pada pharmacokinetics obat. Dalam satu studi tersebut, penghambatan dehidrogenase 11--hydroxysteroid adalah tersangka penyebab penurunan prednisolone clearance antara sehat volunteers.121 sebagai suplemen makanan yang banyak, ada variabilitas intersubject yang besar dalam penyerapan asam glycyrrhetic, penghapusan, keracunan, dan interaksi yang potensial, yang banyak yang mungkin terkait dengan kualitas produk dan pola usage.118,122,123