In vitro Dissolution studiesIn vitr

In vitro Dissolution studies
In vitro dissolution studies of MR tablet formulations prepared were carried in 900 mL of 0.1N HCl with 0.25% w/v SLS as dissolution medium using USP XXI type II (Paddle method) Dissolution Rate Test Apparatus.(LABINDIA, DS 8000) at 50 rpm. The temperature was maintained constant at 37±0.5°C. 5 mL aliquots were withdrawn at different time intervals and filtered using a 0.45µ nylon disc filters and replaced with 5mL of fresh dissolution medium. The filtered samples were suitably diluted if necessary and assayed for OXC by HPLC method. The dissolution experiments were conducted in triplicate

Hasil (Bahasa Indonesia) 2:

Dalam studi Pembubaran vitro
dalam studi disolusi in vitro formulasi tablet MR disiapkan dilakukan di 900 mL 0,1 N HCl dengan 0,25% w / v SLS sebagai medium disolusi menggunakan USP XXI tipe II (metode Paddle) Tingkat Pembubaran Uji Aparatur. (LABINDIA, DS 8000) pada 50 rpm. Suhu dipertahankan konstan pada 37 ± 0,5 ° C. 5 aliquots mL ditarik pada interval waktu yang berbeda dan disaring menggunakan filter disc 0.45μ nilon dan diganti dengan 5 mL medium disolusi segar. Sampel disaring yang sesuai diencerkan jika perlu dan diuji untuk OXC dengan metode HPLC. Percobaan disolusi dilakukan dalam rangkap tiga