Feline viral rhinotracheitis was a

Feline viral rhinotracheitis was a surprisingly severe disease in germfree
cats. The pathogenicity of FRV is apparently not dependent upon
the synergistic activity of the respiratory microbial flora. Clinically and
histologically, experimental feline rhinotracheitis in germfree cats was
similar to the disease in conventional cats. The ulcerative, fibrinopurulent
rhinitis in conventional cats had been attributed chiefly to the activity
of secondary bacterial invaders. In germfree cats, however, the virus
rapidly destroyed virtually all intranasal epithelium. The initial neutrophilic
inflammatory response which ensued was apparently elicited by
products of epithelial necrosis. To our knowledge the lesions produced
by FRV are the most severe of any viral disease reported thus far in
gernfree animals. By contrast, the respiratory and gastrointestinal lesions
which characterize viral diseases such as canine distemper and feline
infectious enteritis are completely absent in germfree animals.
The distribution of lesions produced by FRV in germfree and in conventional
cats is identical, with two exceptions: (1) the bronchial and
bronchiolar lesions, which occurred in germfree cats have not been
previously reported, (2) no lesions were observed in the lingual or oral
mucosa of germfree cats suggesting that the ulcerative glossitis which
sometimes accompanies viral rhinotracheitis in conventional cats 7 may
not be caused by FRV. Despite the severe nasal lesions and abundance of
virus in nasal and pharyngeal fluids, laryngotracheal lesions were mild
and pulmonary lesions confined to bronchi and bronchioles.
Resorption of turbinate bone has been described in experimental
feline rhinotracheitis in conventional cats '1 but osteolytic lesions simulating
overt necrosis of bone were not reported. It was not possible to
determine whether the osteolytic lesions in germfree cats were due to
(1) osteolysis provoked by the severe necrotizing rhinitis, (2) ischemic
necrosis secondary to vascular lesions, or (3) viral infection of osteogenic
cells with subsequent necrosis of bone. Preliminary studies indicate that
FRV inoculated intravenously into susceptible 8-week-old cats, produces
osteolytic lesions in the turbinates which are not preceded by necrosis
of nasal epithelium.15 Focal necrotizing lesions also occur in the primary
spongiosa of the ribs and long bones. Reports relating viruses to lesions
in bone are rare. Only the H-viruses and Rat virus have thus far been
shown to selectively affect bone.16 The apparent alteration in pathogenesis
of infection following intravenous inoculation and the tropism of
the virus for growing bone are presently under investigation.

Hasil (Bahasa Indonesia) 1:

Feline viral rhinotracheitis was a surprisingly severe disease in germfreecats. The pathogenicity of FRV is apparently not dependent uponthe synergistic activity of the respiratory microbial flora. Clinically andhistologically, experimental feline rhinotracheitis in germfree cats wassimilar to the disease in conventional cats. The ulcerative, fibrinopurulentrhinitis in conventional cats had been attributed chiefly to the activityof secondary bacterial invaders. In germfree cats, however, the virusrapidly destroyed virtually all intranasal epithelium. The initial neutrophilicinflammatory response which ensued was apparently elicited byproducts of epithelial necrosis. To our knowledge the lesions producedby FRV are the most severe of any viral disease reported thus far ingernfree animals. By contrast, the respiratory and gastrointestinal lesionswhich characterize viral diseases such as canine distemper and felineinfectious enteritis are completely absent in germfree animals.The distribution of lesions produced by FRV in germfree and in conventionalcats is identical, with two exceptions: (1) the bronchial andbronchiolar lesions, which occurred in germfree cats have not beenpreviously reported, (2) no lesions were observed in the lingual or oralmucosa of germfree cats suggesting that the ulcerative glossitis whichsometimes accompanies viral rhinotracheitis in conventional cats 7 maytidak disebabkan oleh FRV. Meskipun lesi hidung yang parah dan kelimpahanvirus dalam cairan hidung dan faring, laryngotracheal luka-luka ringandan paru lesi terbatas kepada Lungs dan bronchioles.Resorpsi tulang konka telah dijelaskan dalam percobaankucing rhinotracheitis di konvensional kucing ' 1 tapi osteolytic lesi simulasiterang-terangan nekrosis tulang tidak dilaporkan. Itu tidak mungkin untukmenentukan apakah lesi osteolytic di germfree kucing adalah karena(1) osteolysis diprovokasi oleh rhinitis necrotizing parah, (2) iskemiknekrosis sekunder untuk lesi vaskular, atau infeksi virus (3) osteogenicsel-sel dengan berikutnya nekrosis tulang. Studi awal menunjukkan bahwaFRV diinokulasi intravena menjadi rentan 8-minggu-tua kucing, menghasilkanlesi yang osteolytic di turbinates yang tidak didahului oleh nekrosisdari hidung epithelium.15 fokus necrotizing lesi juga terjadi di SDspongiosa tulang rusuk dan tulang panjang. Laporan mengenai virus lesidalam tulang langka. Hanya H-virus dan virus tikus sejauh ini telahditunjukkan untuk selektif mempengaruhi bone.16 perubahan jelas dalam patogenesisinfeksi berikut intravena inokulasi dan tropismevirus untuk tumbuh tulang yang saat ini sedang diselidiki.

Hasil (Bahasa Indonesia) 2:

Rhinotracheitis virus kucing adalah penyakit mengejutkan parah di germfree
kucing. Patogenisitas FRV tampaknya tidak tergantung pada
aktivitas sinergis dari flora mikroba pernapasan. Klinis dan
histologis, kucing eksperimental rhinotracheitis pada kucing germfree adalah
mirip dengan penyakit pada kucing konvensional. The ulseratif, fibrinopurulent
rhinitis pada kucing konvensional telah dikaitkan terutama untuk kegiatan
dari penjajah bakteri sekunder. Pada kucing germfree, namun, virus
cepat hancur hampir semua intranasal epitel. The neutrophilic awal
respon inflamasi yang terjadi tampaknya ditimbulkan oleh
produk dari nekrosis epitel. Untuk pengetahuan kita lesi yang dihasilkan
oleh FRV yang paling parah penyakit virus setiap dilaporkan sejauh ini di
hewan gernfree. Sebaliknya, pernapasan dan pencernaan lesi
yang mencirikan penyakit virus seperti distemper anjing dan kucing
. Menular enteritis benar-benar absen pada hewan germfree
Distribusi lesi yang diproduksi oleh FRV di germfree dan konvensional
kucing identik, dengan dua pengecualian: (1) bronkus dan
lesi bronchiolar, yang terjadi pada kucing germfree belum
dilaporkan sebelumnya, (2) tidak ada lesi yang diamati dalam bahasa atau lisan
mukosa kucing germfree menunjukkan bahwa glositis ulseratif yang
kadang-kadang menyertai rhinotracheitis virus pada kucing konvensional 7 mungkin
tidak disebabkan oleh FRV. Meskipun lesi hidung parah dan kelimpahan
virus di hidung dan faring cairan, lesi laryngotracheal adalah ringan
lesi dan paru terbatas bronkus dan bronkiolus.
Resorpsi tulang konka telah dijelaskan dalam percobaan
kucing rhinotracheitis pada kucing konvensional '1 tetapi lesi osteolitik simulasi
nekrosis terbuka tulang yang tidak dilaporkan. Itu tidak mungkin untuk
menentukan apakah lesi osteolitik pada kucing germfree adalah karena
(1) osteolisis diprovokasi oleh rhinitis necrotizing parah, (2) iskemik
nekrosis sekunder untuk lesi vaskular, atau infeksi virus (3) dari osteogenik
sel dengan nekrosis berikutnya tulang. Studi awal menunjukkan bahwa
FRV diinokulasi secara intravena ke kucing rentan 8-minggu-tua, menghasilkan
lesi osteolitik di turbinat yang tidak didahului oleh nekrosis
dari hidung epithelium.15 lesi necrotizing Focal juga terjadi di primer
spongiosa dari tulang rusuk dan tulang panjang. Laporan yang berkaitan virus untuk lesi
di tulang jarang terjadi. Hanya H-virus dan virus Tikus sejauh ini telah
ditunjukkan untuk selektif mempengaruhi bone.16 The perubahan jelas dalam patogenesis
infeksi berikut inokulasi intravena dan tropisme dari
virus untuk tumbuh tulang saat diselidiki.