Ibuprofen is a non-steroidal anti-i

Ibuprofen is a non-steroidal anti-inflammatory
drug which also has analgesic and antipyretic
activities (Mycek et al., 2000). The drug is
practically very slightly soluble, but it is readily
absorbed from the gastrointestinal tract. This drug
causes irritation of gastric mucous membrane. It is
also unstable to light. Hence, microencapsulation
of the drug in a polymeric shell would be of
advantage to these drawbacks.
The use of new natural hydrophilic polymers as
drug carriers has received considerable attention
in recent decades (Remunan-Lopez and
Bodmeier, 1996). Grewia gum is a polysaccharide
gum derived from the inner stem bark of edible
plant Grewia mollis Juss. (Family Tiliaceae). The
plant is a shrub abundant in the savannah region
of West Africa. The leaves and bark of the plant
contain gum. In Nigeria, the dried and pulverized
inner stem bark of the plants is used as a
thickening agent in some local dishes (Okafor
and Chukwu, 2003).
Grewia gum is one of the gums that have
potential application in pharmaceutical
formulations. The gum is reported to be
compatible with many drugs and excipients
(Okafor et al., 2001). The isolation, chemical
contents, physicochemical and rheological
properties of the gum has been reported
elsewhere (Okafor et al., 2001). Also the binding
property, mechanical properties, water vapor
permeability of the gum film as well as the
influence of granulating solvents on drug release
from tablets containing grewia gum have been
reported (Okafor et al., 2003; Okafor et al., 2004).
But, no report had been given on the application
of the gum in microencapsulation.
Several kinds of preparations such as tablets,
capsules and coated pellets have been
suggested for use as oral extended release
formulations. In order to formulate drug powder
into these dosage forms, it is very important to
assess its flow properties. The physical, chemical
and pharmacologic properties of a drug are
affected by the size, surface area and surface to
volume ratio of a drug particle. Particle size of
material used in formulation of suspension,
emulsions and tablets is of great importance.
Also, the dissolution rate of drug powders and its
stability is greatly affected by the particle size
distribution (Ozyazici, 1996).
The aim of this work is to investigate the effect of
microencapsulation process on the
compressibility and compactibility of ibuprofen
powder using gelatin-grewia gum in comparison
to that of gelatin-acacia gum. Hence, the flow
rate, angle of repose, bulk density, tapped
density, true density and mean particle size of the
microcapsules were determined. The sustained
release dosage forms can be obtained by either

Hasil (Bahasa Indonesia) 1:

Ibuprofen adalah anti-inflamasi non-steroid obat yang juga memiliki analgesik dan antipiretik kegiatan (Mycek et al., 2000). Obat ini praktis sangat sedikit larut, tetapi mudah diserap dari saluran gastrointestinal. Obat ini menyebabkan iritasi membran mukosa lambung. Itu juga tidak stabil cahaya. Oleh karena itu, enkapsulasi mikro obat dalam shell Polimerik akan keuntungan untuk kelemahan ini. Penggunaan baru polimer hidrofil alami sebagai operator obat telah menerima perhatian dalam beberapa dekade terakhir (Remunan-Lopez dan Bodmeier, 1996). Grewia karet adalah polisakarid permen karet yang berasal dari kulit batang batin dapat dimakan tanaman Grewia mollis Juss. (Keluarga Malvaceae). The tanaman adalah sebuah semak yang melimpah di wilayah savannah Afrika Barat. Daun dan batang tanaman berisi permen karet. Di Nigeria, kering dan bubuk kulit batang batin tanaman digunakan sebagai agen penebalan dalam beberapa hidangan lokal (Okafor dan Chukwu, 2003). Grewia karet adalah salah satu gusi yang memiliki potensial aplikasi di farmasi formulasi. Permen karet dilaporkan kompatibel dengan banyak obat dan excipients (Okafor et al., 2001). Isolasi, kimia isi, secara fisikokimia maupun rheological sifat gusi telah dilaporkan di tempat lain (Okafor et al., 2001). Juga mengikat properti, sifat mekanik, uap air permeabilitas film gusi serta pengaruh granulating pelarut pada rilis obat from tablets containing grewia gum have been reported (Okafor et al., 2003; Okafor et al., 2004). But, no report had been given on the application of the gum in microencapsulation. Several kinds of preparations such as tablets, capsules and coated pellets have been suggested for use as oral extended release formulations. In order to formulate drug powder into these dosage forms, it is very important to assess its flow properties. The physical, chemical and pharmacologic properties of a drug are affected by the size, surface area and surface to volume ratio of a drug particle. Particle size of material used in formulation of suspension, emulsions and tablets is of great importance. Also, the dissolution rate of drug powders and itsstability is greatly affected by the particle size distribution (Ozyazici, 1996). The aim of this work is to investigate the effect of microencapsulation process on the compressibility and compactibility of ibuprofen powder using gelatin-grewia gum in comparison to that of gelatin-acacia gum. Hence, the flow rate, angle of repose, bulk density, tapped density, true density and mean particle size of the microcapsules were determined. The sustained release dosage forms can be obtained by either