Diagnosis of chronic endometritis i

Diagnosis of chronic endometritis in biopsies with stromal breakdown
Author: Gilmore, Hannah; Fleischhacker, Deborah; Hecht, Jonathan L.
ProQuest document link
Abstract: Plasma cells are the hallmark of chronic endometritis but are not specific for upper tract infection.
Plasma cells have also been noted in hormonally mediated endometrial disorders in association with gland
architectural changes ("disordered proliferativeâ[euro] and "anovulatoryâ[euro] patterns), and stromal
breakdown. We reviewed benign endometrial biopsies diagnosed at Beth Israel Deaconess Medical Center over
a 2-year period described as disordered/anovulatory patterns ± stromal breakdown. Cases were excluded if
tissue was not available; women were younger than 50 years where most diagnoses were atrophic or cancer; or
diagnoses were secretory, menstrual endometrium, or polyps. The remaining 61 cases were compared to 33
samples of unremarkable proliferative endometrium. Plasma cells were quantified on hematoxylin and eosinstained
sections and using a histochemical stain methyl green pyronin. The indication for biopsy was an
abnormal pattern of bleeding in 34 cases, infertility workup in 7, incidental part of workup for pain, or other
findings in 5. The majority of disordered proliferative endometrium had plasma cells (61% grade 1, 17% grade
2) all seen on methyl green pyronin staining only. Two thirds of proliferative endometrium with breakdown
showed plasma cells (19% grade 1, 39% grade 2, 10 % grade 3). Plasma cells were rare in inactive
endometrium and noted in only 18% of unremarkable proliferative endometrium, all grade 1. Plasma cells are
commonly present in the endometrium of women with dysfunctional uterine bleeding and focal stromal
breakdown. Given the lack of clinical evidence for infection, the inflammation likely represents a physiologic
process.

Hasil (Bahasa Indonesia) 1:

Diagnosis kronis endometritis pada biopsi dengan kerusakan stromaPengarang: Gilmore, Hannah; Fleischhacker, Debora; Hecht, Jonathan L.Link dokumen proQuestAbstrak: sel Plasma ciri khas kronis endometritis tetapi tidak spesifik untuk infeksi saluran atas.Sel plasma juga telah dicatat dalam hormon ditengahi endometrium gangguan dalam hubungan dengan kelenjarperubahan arsitektur ("acakan proliferativeâ [euro] dan"pola anovulatoryâ [euro]), dan stromarincian. Kami meninjau jinak biopsi endometrium didiagnosis di Beth Israel diakones Medical Center atasperiode 2-tahun digambarkan sebagai pola-pola yang teratur/anovulatory ± kerusakan stroma. Kasus dikeluarkan jikaJaringan itu tidak tersedia; wanita lebih muda dari 50 tahun yang mana kebanyakan diagnosa yang atrophic atau kanker; ataudiagnosa yang sekresi, menstruasi endometrium, atau polip. Kasus 61 sisa dibandingkan dengan 33sampel endometrium proliferatif biasa-biasa saja. Sel plasma yang diukur pada hematoxylin dan eosinstainedBagian dan menggunakan pyronin metil hijau histokimia noda. Indikasi untuk biopsipola abnormal pendarahan dalam kasus 34, pemeriksaan infertilitas di 7, insidental bagian dari pemeriksaan untuk sakit, atau lainnyatemuan-temuan di 5. Mayoritas acakan proliferatif endometrium memiliki sel plasma (61% kelas 1, kelas 17%2) semua terlihat pada metil pyronin hijau pewarnaan hanya. Dua pertiga dari proliferatif endometrium dengan rincianmenunjukkan sel plasma (19% kelas 1, kelas 39% 10% kelas 2, 3). Sel plasma yang jarang terjadi di tidak aktifendometrium dan dicatat dalam hanya 18% dari endometrium proliferatif biasa-biasa saja, semua kelas 1. Sel-sel plasmasering hadir dalam endometrium perempuan dengan pendarahan rahim disfungsional dan fokus stromarincian. Mengingat kurangnya bukti klinis untuk infeksi, peradangan mungkin mewakili fisiologisproses.