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We next calculated the growth-rate
We next calculated the growth-rate dependence of the ribosomal
and T-fractions under translation-limited growth, as studied
in ref. 11 using ribosome-targeting antibiotics, which is implemented
in the model by reducing the maximal translation speed
γmax for constant ν (dashed red lines in Fig. 3). With decreasing
γmax, the ribosomal fraction increases as observed with increasing
antibiotic concentrations (11). It exhibits a linear dependence on
the growth rate and extrapolates to a maximal ribosomal fraction
that is independent of the nutrient quality ν, i.e., independent
and T-fractions under translation-limited growth, as studied
in ref. 11 using ribosome-targeting antibiotics, which is implemented
in the model by reducing the maximal translation speed
γmax for constant ν (dashed red lines in Fig. 3). With decreasing
γmax, the ribosomal fraction increases as observed with increasing
antibiotic concentrations (11). It exhibits a linear dependence on
the growth rate and extrapolates to a maximal ribosomal fraction
that is independent of the nutrient quality ν, i.e., independent
0/5000
We next calculated the growth-rate dependence of the ribosomaland T-fractions under translation-limited growth, as studiedin ref. 11 using ribosome-targeting antibiotics, which is implementedin the model by reducing the maximal translation speedγmax for constant ν (dashed red lines in Fig. 3). With decreasingγmax, the ribosomal fraction increases as observed with increasingantibiotic concentrations (11). It exhibits a linear dependence onthe growth rate and extrapolates to a maximal ribosomal fractionthat is independent of the nutrient quality ν, i.e., independent
Sedang diterjemahkan, harap tunggu..
Kami selanjutnya dihitung ketergantungan pertumbuhan laju ribosom
dan T-fraksi di bawah pertumbuhan terjemahan terbatas, sebagaimana dipelajari
di ref. 11 menggunakan ribosom-penargetan antibiotik, yang diimplementasikan
dalam model dengan mengurangi kecepatan maksimal terjemahan
γmax untuk ν konstan (garis putus-putus merah pada Gambar. 3). Dengan penurunan
γmax, fraksi meningkat ribosom seperti yang diamati dengan meningkatnya
konsentrasi antibiotik (11). Ini menunjukkan ketergantungan linear pada
tingkat pertumbuhan dan mengekstrapolasikan untuk sebagian ribosom maksimal
yang independen dari kualitas ν gizi, yaitu, independen
dan T-fraksi di bawah pertumbuhan terjemahan terbatas, sebagaimana dipelajari
di ref. 11 menggunakan ribosom-penargetan antibiotik, yang diimplementasikan
dalam model dengan mengurangi kecepatan maksimal terjemahan
γmax untuk ν konstan (garis putus-putus merah pada Gambar. 3). Dengan penurunan
γmax, fraksi meningkat ribosom seperti yang diamati dengan meningkatnya
konsentrasi antibiotik (11). Ini menunjukkan ketergantungan linear pada
tingkat pertumbuhan dan mengekstrapolasikan untuk sebagian ribosom maksimal
yang independen dari kualitas ν gizi, yaitu, independen
Sedang diterjemahkan, harap tunggu..
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- Je me leve vers aux tombes. Je vais a la
