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Suppression of termination Suppress
Suppression of termination
Suppression of termination occurs during translation of may viral mRNAs as a means of generating a second protein with extended carboxy terminus. In retroviruses, gag and pol genes are encoded by a single mRNA and separated by an amber termination codon UAG. Translational suppression of the amber codon allows synthesis of the gag pol precursor.
A similar strategy is used by tobacco mosaic virus to translate its replicase proteins.
Translation suppression is mediated by suppressor tRNAs that can recognize termination codons and insert a specific amino acid. The nucleotide sequence 3’ of the termination codon also plays an important role in the efficiency of translational suppression.
Suppression of termination occurs during translation of may viral mRNAs as a means of generating a second protein with extended carboxy terminus. In retroviruses, gag and pol genes are encoded by a single mRNA and separated by an amber termination codon UAG. Translational suppression of the amber codon allows synthesis of the gag pol precursor.
A similar strategy is used by tobacco mosaic virus to translate its replicase proteins.
Translation suppression is mediated by suppressor tRNAs that can recognize termination codons and insert a specific amino acid. The nucleotide sequence 3’ of the termination codon also plays an important role in the efficiency of translational suppression.
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Penindasan penghentian Penindasan penghentian terjadi selama terjemahan Mei virus mRNAs sebagai sarana untuk menghasilkan protein kedua dengan karboksi diperpanjang terminus. Dalam retrovirus, muntah dan pol gen dikodekan oleh mRNA satu dan dipisahkan oleh amber penghentian kodon UAG. Translasi penindasan kodon kuning memungkinkan sintesis gag pol pendahulu. Strategi yang sama digunakan oleh virus mosaik tembakau untuk menerjemahkan protein replicase. Terjemahan penindasan diperantarai oleh tRNAs penekan yang dapat mengenali penghentian codons dan memasukkan asam amino tertentu. Urutan nukleotida 3' dari penghentian kodon juga memainkan peran penting dalam efisiensi translational penindasan.
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