Immunostaining for cytokeratin 7 (C

Immunostaining for cytokeratin 7 (CK7) and cytokeratin 20 (CK20) has a characteristic pattern in Barrett’s esophagus (BE), but reports regarding its sensitivity and specificity are inconsistent. Intestinal metaplasia of the gastric cardia (CIM) is histologically similar to BE, but with no abnormal endoscopic findings.

OBJECTIVES:
To evaluate the sensitivity and specificity of a semi-quantitative CK7/CK20 immunostaining pattern for the diagnosis of BE, and to further elucidate the pathogenesis of CIM.

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Immunostaining for cytokeratin 7 (CK7) and cytokeratin 20 (CK20) has a characteristic pattern in Barrett’s esophagus (BE), but reports regarding its sensitivity and specificity are inconsistent. Intestinal metaplasia of the gastric cardia (CIM) is histologically similar to BE, but with no abnormal endoscopic findings.OBJECTIVES:To evaluate the sensitivity and specificity of a semi-quantitative CK7/CK20 immunostaining pattern for the diagnosis of BE, and to further elucidate the pathogenesis of CIM.

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Immunostaining untuk cytokeratin 7 (CK7) dan cytokeratin 20 (CK20) memiliki pola karakteristik di esophagus Barrett (BE), namun laporan mengenai sensitivitas dan spesifisitas tidak konsisten. Metaplasia usus kardia lambung (CIM) adalah histologi mirip dengan BE, tetapi dengan tidak ada temuan endoskopi yang abnormal. TUJUAN: Untuk mengevaluasi sensitivitas dan spesifisitas dari CK7 / CK20 immunostaining pola semi-kuantitatif untuk diagnosis BE, dan untuk lebih menjelaskan patogenesis CIM.

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