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Bonferroni's multiple testing corre
Bonferroni's multiple testing correction
All traits were tested for associations to cis-ortrans-acting SNPs individually. Study-wise individual cutoff levels were calculated to test for cis- and trans-associations. To derive a study-wise cis-cutoff level at significance level [alpha] = 0.05, we first determined all cis-acting SNPs within the data set. To allow for detailed comparisons of our results with those of Schadt et al., (16) we used the same definitions, that is, cis-acting SNPs are those that occur within 1 Mb upstream or downstream of the known or predicted 50- and 30-ends of any trait gene. Thus, the study-wise Bonferroni-adjusted P-value threshold equals 0.05/2 607 664 = 1.92 x [10.sup.-8], where 2 607 664 is the total number of possible cis-associations based on the above definition. Accordingly, the study-wise trans-specific Bonferroni's cutoff level was computed as the total number of tests for trans-associations, that is, 0.05/4.6 billion = 1.08 x [10.sup.-11].
All traits were tested for associations to cis-ortrans-acting SNPs individually. Study-wise individual cutoff levels were calculated to test for cis- and trans-associations. To derive a study-wise cis-cutoff level at significance level [alpha] = 0.05, we first determined all cis-acting SNPs within the data set. To allow for detailed comparisons of our results with those of Schadt et al., (16) we used the same definitions, that is, cis-acting SNPs are those that occur within 1 Mb upstream or downstream of the known or predicted 50- and 30-ends of any trait gene. Thus, the study-wise Bonferroni-adjusted P-value threshold equals 0.05/2 607 664 = 1.92 x [10.sup.-8], where 2 607 664 is the total number of possible cis-associations based on the above definition. Accordingly, the study-wise trans-specific Bonferroni's cutoff level was computed as the total number of tests for trans-associations, that is, 0.05/4.6 billion = 1.08 x [10.sup.-11].
0/5000
Bonferroni's beberapa pengujian koreksi
ciri-ciri semua diuji untuk Asosiasi untuk SNP cis-ortrans-bertindak secara individual. Study-Wise tingkat cutoff individu yang dihitung untuk menguji untuk cis - dan trans-Asosiasi. Untuk memperoleh study-wise cis-cutoff tingkat kepentingan tingkat [alpha] = 0.05, kita pertama menentukan semua SNP cis-bertindak dalam data set. Untuk memungkinkan rinci perbandingan hasil kami dengan orang-orang dari Schadt et al., (16) kami menggunakan definisi yang sama, yaitu SNP cis-bertindak adalah mereka yang terjadi dalam 1 Mb hulu hilir dari dikenal atau diperkirakan 50 - dan 30-ujung gen sifat apapun atau. Dengan demikian, study-wise Bonferroni-disesuaikan P-nilai threshold sama dengan 0,05 2 607 664 = 1.92 x [10.sup.-8], dimana 2 607 664 adalah jumlah mungkin cis-Asosiasi berdasarkan definisi di atas. Dengan demikian, study-wise trans-spesifik Bonferroni's cutoff tingkat dihitung sebagai jumlah tes untuk trans-Asosiasi, yaitu 0,05/4,6 miliar = x 1,08 [10.sup.-11].
ciri-ciri semua diuji untuk Asosiasi untuk SNP cis-ortrans-bertindak secara individual. Study-Wise tingkat cutoff individu yang dihitung untuk menguji untuk cis - dan trans-Asosiasi. Untuk memperoleh study-wise cis-cutoff tingkat kepentingan tingkat [alpha] = 0.05, kita pertama menentukan semua SNP cis-bertindak dalam data set. Untuk memungkinkan rinci perbandingan hasil kami dengan orang-orang dari Schadt et al., (16) kami menggunakan definisi yang sama, yaitu SNP cis-bertindak adalah mereka yang terjadi dalam 1 Mb hulu hilir dari dikenal atau diperkirakan 50 - dan 30-ujung gen sifat apapun atau. Dengan demikian, study-wise Bonferroni-disesuaikan P-nilai threshold sama dengan 0,05 2 607 664 = 1.92 x [10.sup.-8], dimana 2 607 664 adalah jumlah mungkin cis-Asosiasi berdasarkan definisi di atas. Dengan demikian, study-wise trans-spesifik Bonferroni's cutoff tingkat dihitung sebagai jumlah tes untuk trans-Asosiasi, yaitu 0,05/4,6 miliar = x 1,08 [10.sup.-11].
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Bonferroni's multiple testing correction
All traits were tested for associations to cis-ortrans-acting SNPs individually. Study-wise individual cutoff levels were calculated to test for cis- and trans-associations. To derive a study-wise cis-cutoff level at significance level [alpha] = 0.05, we first determined all cis-acting SNPs within the data set. To allow for detailed comparisons of our results with those of Schadt et al., (16) we used the same definitions, that is, cis-acting SNPs are those that occur within 1 Mb upstream or downstream of the known or predicted 50- and 30-ends of any trait gene. Thus, the study-wise Bonferroni-adjusted P-value threshold equals 0.05/2 607 664 = 1.92 x [10.sup.-8], where 2 607 664 is the total number of possible cis-associations based on the above definition. Accordingly, the study-wise trans-specific Bonferroni's cutoff level was computed as the total number of tests for trans-associations, that is, 0.05/4.6 billion = 1.08 x [10.sup.-11].
All traits were tested for associations to cis-ortrans-acting SNPs individually. Study-wise individual cutoff levels were calculated to test for cis- and trans-associations. To derive a study-wise cis-cutoff level at significance level [alpha] = 0.05, we first determined all cis-acting SNPs within the data set. To allow for detailed comparisons of our results with those of Schadt et al., (16) we used the same definitions, that is, cis-acting SNPs are those that occur within 1 Mb upstream or downstream of the known or predicted 50- and 30-ends of any trait gene. Thus, the study-wise Bonferroni-adjusted P-value threshold equals 0.05/2 607 664 = 1.92 x [10.sup.-8], where 2 607 664 is the total number of possible cis-associations based on the above definition. Accordingly, the study-wise trans-specific Bonferroni's cutoff level was computed as the total number of tests for trans-associations, that is, 0.05/4.6 billion = 1.08 x [10.sup.-11].
Sedang diterjemahkan, harap tunggu..
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