DIFFUSION ACROSS BIOLOGICAL MEMBRAN

DIFFUSION ACROSS BIOLOGICAL MEMBRANES

Diffusive fluxes of uncharged molecules across lipid bilayer membranes are usually represented by Fick’s First Law of Diffusion

J dn/dt DA(dC/dx)

where D diffusion coefficient for molecule in the barrier (cm2/sec), A surface area of the barrier (cm2), dC/dx change in concentration over distance
in the barrier (mol cm3 cm1), and J dn/dt change in number of moles per unit time (mol/s).

The diffusion coefficient (D) is derived from the Stokes-Einstein equation that models the diffusion of spherical particles in a continuous fluid medium and represents the mobility of the solute in the membrane. The diffusion coefficient

D kT/6r

0/5000

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DIFFUSION ACROSS BIOLOGICAL MEMBRANESDiffusive fluxes of uncharged molecules across lipid bilayer membranes are usually represented by Fick’s First Law of DiffusionJ dn/dt DA(dC/dx)where D diffusion coefficient for molecule in the barrier (cm2/sec), A surface area of the barrier (cm2), dC/dx change in concentration over distancein the barrier (mol cm3 cm1), and J dn/dt change in number of moles per unit time (mol/s).The diffusion coefficient (D) is derived from the Stokes-Einstein equation that models the diffusion of spherical particles in a continuous fluid medium and represents the mobility of the solute in the membrane. The diffusion coefficientD kT/6r

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DIFUSI ACROSS BIOLOGI MEMBRAN

difusi fluks molekul bermuatan melintasi membran bilayer lipid biasanya diwakili oleh Fick Hukum Pertama Difusi

J? dn / dt? ? DA (dC / dx)

di mana D? koefisien difusi untuk molekul dalam barrier (cm2 / detik), A? luas permukaan penghalang (cm2), dC / dx? mengubah konsentrasi lebih jauh
di penghalang (mol? cm? 3? cm? 1), dan J? dn / dt? perubahan jumlah mol per satuan waktu (mol / s).

Koefisien difusi (D) berasal dari persamaan Stokes-Einstein bahwa model difusi partikel berbentuk bola dalam medium cairan terus menerus dan merupakan mobilitas zat terlarut di dalam membran . Koefisien difusi

D? kT / 6? r?

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