The folkloric claim of Musa paradis

The folkloric claim of Musa paradisiaca sap in the management of diarrhoea is yet to be substantiated or refuted with scientific data. Therefore, the aim of the current study was to screen the sap of M. paradisiaca for both its secondary metabolites and antidiarrhoeal activity at 0.25, 0.50, and 1.00 mL in rats. Secondary metabolites were screened using standard methods while the antidiarrhoeal activity was done by adopting the castor oil-induced diarrhoeal, castor oil-induced enteropooling, and gastrointestinal motility models. The sap contained flavonoids, phenolics, saponins, alkaloids, tannins, and steroids while cardiac glycosides, anthraquinones, triterpenes, cardenolides, and dienolides were not detected. In the castor oil-induced diarrhoeal model, the sap significantly (P < 0.05) prolonged the onset time of diarrhoea, decreased the number, fresh weight, and water content of feaces, and increased the inhibition of defecations. Na+-K+-ATPase activity in the small intestine increased significantly whereas nitric oxide content decreased. The decreases in the masses and volumes of intestinal fluid by the sap were accompanied by increase in inhibition of intestinal fluid content in the enteropooling model. The sap decreased the charcoal meal transit in the gastrointestinal motility model. In all the models, the 1.00 mL of the sap produced changes that compared well with the reference drugs. Overall, the antidiarrhoeal activity of Musa paradisiaca sap attributed to the presence of alkaloids, phenolics, flavonoids, and/or saponins which may involve, among others, enhancing fluid and electrolyte absorption through de novo synthesis of the sodium potassium ATPase and/or reduced nitric oxide levels.

Hasil (Bahasa Indonesia) 2:

The folkloric klaim Musa paradisiaca getah dalam manajemen diare belum dibuktikan atau dibantah dengan data ilmiah. Oleh karena itu, tujuan dari penelitian ini adalah untuk menyaring getah M. paradisiaca untuk kedua metabolit sekunder dan aktivitas antidiare sebesar 0,25, 0,50, dan 1,00 mL pada tikus. metabolit sekunder disaring menggunakan metode standar sementara aktivitas antidiare dilakukan dengan mengadopsi castor diare yang disebabkan minyak, jarak enteropooling diinduksi minyak, dan model motilitas gastrointestinal. getah mengandung flavonoid, phenolic, saponin, alkaloid, tanin, dan steroid sementara glikosida jantung, antrakuinon, triterpen, cardenolides, dan dienolides tidak terdeteksi. Dalam model diare castor oil-diinduksi, getah signifikan (P <0,05) memperpanjang waktu timbulnya diare, penurunan jumlah, berat segar, dan kadar air feaces, dan meningkatkan penghambatan buang air besar. Na + -K + -ATPase di usus kecil meningkat secara signifikan sedangkan konten oksida nitrat menurun. Penurunan dalam massa dan volume cairan usus dengan getah didampingi peningkatan penghambatan konten cairan usus dalam model enteropooling. getah menurun makan arang transit di model motilitas gastrointestinal. Di semua model, 1,00 mL getah yang dihasilkan perubahan yang baik dibandingkan dengan obat-obatan referensi. Secara keseluruhan, aktivitas antidiare dari Musa paradisiaca getah dikaitkan dengan kehadiran alkaloid, fenolat, flavonoid, dan / atau saponin yang mungkin melibatkan, antara lain, meningkatkan cairan dan elektrolit penyerapan melalui de novo sintesis dari ATPase natrium kalium dan / atau mengurangi nitrat tingkat oksida.