DISCUSSIONIt is known that the neur

DISCUSSION
It is known that the neuroendocrine growth axis is involved in the activity of many hormones, cytokines, and chemokines and their receptors play crucial roles in the regulation of animal growth, reproduction, immunity, and metabolism. At present, it has become a hot topic in research to probe into balanced selection and breeding for growth, reproduction, immunity, and metabolism in chickens for optimum performance. Combining the relative information with comparative omics (such as genomics, transcriptomics, proteomics, and metabonomics), physiological functions, mapping and fine mapping of QTL and expression QTL, signaling pathways, and gene networks, the method of the candidate gene approach is becoming increasingly economical and effective in finding candidate QTL gene and quantitative trait nucleotides with significant effects on economically important traits (Kanehisa and Goto, 2000; Cogburn et al., 2003; Zhu and Zhao, 2007; Kuhn et al., 2008). According to the above integration strategies, the IGFBP1, IGFBP3, and STAT5B genes were effectively selected and used to study the association with growth and reproductive traits in chickens.

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DISKUSIHal ini diketahui bahwa sumbu neuroendokrin pertumbuhan yang terlibat dalam kegiatan banyak hormon, sitokin, dan chemokines dan reseptor mereka memainkan peranan yang penting dalam peraturan pertumbuhan hewan, reproduksi, kekebalan, dan metabolisme. Saat ini, telah menjadi topik panas di penelitian untuk menggali pilihan seimbang dan berkembang biak untuk pertumbuhan, reproduksi, kekebalan, dan metabolisme dalam ayam untuk kinerja yang optimal. Menggabungkan informasi relatif dengan perbandingan neraca (seperti genomics, transcriptomics, proteomik dan metabonomics), fungsi fisiologis, pemetaan dan halus pemetaan QTL dan ekspresi QTL, menandakan jalur, dan jaringan gen, metode pendekatan gen calon menjadi semakin ekonomis dan efektif dalam mencari calon QTL gen dan nukleotida sifat kuantitatif dengan efek yang signifikan pada ciri-ciri penting secara ekonomi (Kanehisa dan Goto, 2000; Cogburn et al., 2003; Zhu dan Zhao, 2007; Kuhn et al., 2008). Menurut strategi integrasi di atas, IGFBP1, IGFBP3, dan STAT5B gen secara efektif dipilih dan digunakan untuk belajar asosiasi dengan ciri-ciri pertumbuhan dan reproduksi di ayam.