Adaptation by Decreasing Delivery t

Adaptation by Decreasing Delivery to the Target The first step
in the development of toxicity is delivery of the ultimate toxicant (a
xenobiotic, its metabolite or xenobiotic-generated ROS and RNS)
to the target (Fig. 3-2). Certain chemicals induce adaptive changes
that lessen their delivery by diminishing the absorption, increasing
their sequestration by intracellular binding proteins, enhancing their
detoxication, or promoting their cellular export

Hasil (Bahasa Indonesia) 2:

Adaptasi dengan Penurunan Pengiriman ke Target Langkah pertama
dalam pengembangan toksisitas pengiriman racun utama (a
xenobiotik, metabolit atau xenobiotik yang dihasilkan ROS dan RNS)
ke target (Gambar. 3-2). Bahan kimia tertentu menginduksi perubahan adaptif
yang mengurangi pengiriman mereka dengan mengurangi penyerapan, meningkatkan
penyerapan mereka dengan intraseluler mengikat protein, meningkatkan mereka
detoxication, atau mempromosikan ekspor selular mereka