Evidence for the proposed mechanism

Evidence for the proposed mechanism
is insufficient in vivo, but some studies
have reported benefits from gluco -
samine in terms of pain relief and even
radiographic progression.1
Evidence for a positive effect is
controversial, however, with several
studies showing no benefit over pla -
cebo.1,2 The Osteoarthritis Research
Society International (OARSI) guidelines
state that “treatment with glucosamine
and/or chondroitin sulphate
may provide symptomatic benefit in
patients with knee OA,” but “if no
response is apparent within 6 months
treatment should be discontinued.”2
Other guidelines, such as those for the
American Academy of Orthopaedic
Surgeons, make a recommendation
that physicians not prescribe glucosamine.
3 Both sets of guidelines are
based on level I evidence.2,3
This disparity in recommend -
ations is considered to be due to the
heterogeneity of existing studies,
particularly with respect to adequacy of allocation concealment.2 Little or
no benefit has been observed when
concealment is adequate.2 Evidence
regarding chon droitin sulfate is similarly
inconsistent.2 There is marked
heterogeneity of outcomes between
trials, and again higher-quality studies
with adequate concealment have
been unable to show significant benefit.
1,2
Overall, the evidence and recommendations
remain inconsistent for
both glucosamine and chondroitin.1-3
We do not recommend prescription of
these supplements as their benefit
remains unproven, but the risk of their
use seems limited to mild stomach
upset and the cost of the pills.1-3A trial
of treatment for 6 months would not
be unreasonable if a patient expresses
great interest in such products. Future
independent high-quality studies are
required to further clarify the efficacy
of both agents.

Hasil (Bahasa Indonesia) 1:

Bukti untuk mekanisme yang diusulkantidak cukup di vivo, tetapi beberapa studitelah melaporkan manfaat dari gluco-samine dalam rasa sakit dan bahkanRadiografi progression.1Bukti untuk efek positifkontroversial, namun, dengan beberapastudi menunjukkan manfaat tanpa atas pla -Cebo.1,2 The Osteoarthritis penelitianMasyarakat internasional (OARSI) pedomanmenyatakan bahwa "pengobatan dengan glukosamindan/atau kondroitin sulfatmungkin memberikan gejala keuntungan dalampasien dengan lutut OA", tetapi"jika tidak adaTanggapan jelas dalam waktu 6 bulanperawatan harus dihentikan." 2Pedoman lain, seperti untukAmerican Academy of OrthopaedicAhli bedah, membuat rekomendasibahwa tidak resep dokter glukosamin.3 kedua set pedomanBerdasarkan level saya evidence.2,3Ini perbedaan dalam merekomendasikan-ations dianggap karenaheterogenitas studi yang ada,khususnya sehubungan dengan kecukupan alokasi concealment.2 kecil atauada manfaat telah diamati ketikapenyembunyian adalah adequate.2 buktimengenai chon droitin sulfat adalah samainconsistent.2 tidak ditandaiheterogenitas hasil antarauji, dan sekali lagi penelitian berkualitas tinggidengan memadai penyembunyian memilikimampu menunjukkan manfaat yang signifikan.1,2Secara keseluruhan, bukti dan rekomendasitetap konsisten untukglukosamin dan chondroitin.1-3Kami tidak menganjurkan resepsuplemen ini sebagai manfaat merekatetap belum terbukti, tapi risiko merekapenggunaan tampaknya terbatas ringan perutmarah dan biaya sidang pills.1-3Apengobatan untuk 6 bulan tidak akanakan masuk akal jika pasien mengungkapkanminat besar dalam produk tersebut. Masa depanindependen studi berkualitas tinggidiperlukan untuk lebih memperjelas kemanjurankedua agen.