Rabies virus is a single-strand, ne

Rabies virus is a single-strand, negative-sense RNA virus
of the family Rhabdoviridae. Its nonsegmented genomic
RNA acts as a template for both transcription and replication.
During the transcription process, a positive-strand
leader RNA and five monocistronic mRNAs are synthesized,
whereas during the RNA replication process, a full length,
positive-strand RNA (replicative intermediate) is synthesized,
which serves as the template for the synthesis of
progeny negative-strand genomic RNA (Wunner, 1991). The
progeny genomic RNA is encapsidated with nucleoprotein
(N) and this RNA–N complex, together with the nominal
viral phosphoprotein (P, also designated NS or M1) and
RNA polymerase (L), forms the active cytoplasmic ribonucleoprotein
(RNP) complex in virus-infected cells and the
RNP core in virus particles (Sokol et al., 1971). The RNP
complex alone is capable of initiating viral RNA transcription
and replication in vivo and in vitro. Recent studies of
rabies viral protein functions using reverse genetics demonstrated
that N, P, and L in the RNP complex are all
required for rabies virus RNA transcription and replication
(Conzelmann and Schnell 1994; Schnell et al., 1994). However,
the sequence of events, specificity, and mode(s) of
interaction between each of these proteins and between
these proteins and the genomic RNA which results in viral
RNA transcription and replication has not been defined

Hasil (Bahasa Indonesia) 2:

Virus rabies adalah, negatif-sense virus RNA untai tunggal
dari keluarga Rhabdoviridae. Its genom nonsegmented
RNA bertindak sebagai template untuk kedua transkripsi dan replikasi.
Selama proses transkripsi, positif-untai
RNA pemimpin dan lima mRNA monosistronik disintesis,
sedangkan selama proses replikasi RNA, panjang penuh,
RNA positif-strand (replikatif menengah ) disintesis,
yang berfungsi sebagai template untuk sintesis
keturunan negatif-strand RNA genomik (Wunner, 1991). The
keturunan RNA genomik encapsidated dengan nukleoprotein
(N) dan ini kompleks RNA-N, bersama-sama dengan nominal
phosphoprotein virus (P, NS juga ditunjuk atau M1) dan
RNA polimerase (L), membentuk ribonucleoprotein sitoplasma aktif
(RNP) yang kompleks di sel yang terinfeksi virus dan
inti RNP di partikel virus (Sokol et al., 1971). The RNP
kompleks sendiri mampu memulai viral transkripsi RNA
dan replikasi in vivo dan in vitro. Studi terbaru dari
rabies virus fungsi protein menggunakan reverse genetic menunjukkan
bahwa N, P, dan L di kompleks RNP semua
diperlukan untuk virus rabies RNA transkripsi dan replikasi
(Conzelmann dan Schnell 1994; Schnell et al., 1994). Namun,
urutan kejadian, spesifisitas, dan modus (s) dari
interaksi antara masing-masing protein dan antara
protein dan RNA genom yang menghasilkan viral
transkripsi RNA dan replikasi belum didefinisikan