Table 2 shows the 74 ADME associati

Table 2 shows the 74 ADME associations (68 cis-acting and 6 trans-acting) uniquely identified in our study, which mapped to 31 different trait genes. Closer analysis showed that the corresponding SNPs had indeed been analyzed but were not significantly associated with expression in the former study. (16) These unique associations included additional SNPs for traits mentioned in Table 1 but with LD of [r.sup.2]

Hasil (Bahasa Indonesia) 1:

Tabel 2 menunjukkan Asosiasi ADME 74 (68 cis-bertindak dan 6 trans-sementara) secara unik diidentifikasi dalam studi kami, yang dipetakan ke 31 gen sifat yang berbeda. Dekat analisis menunjukkan bahwa SNP sesuai memang telah dikaji tetapi tidak bermakna dikaitkan dengan ekspresi dalam studi mantan. (16) Asosiasi unik ini termasuk tambahan SNP untuk Ciri-ciri yang disebutkan dalam tabel 1 tapi dengan LD dari [r.sup.2]<0.8 (misalnya, ARNT, beberapa GSTs, VKORC1) dan tambahan ADME dan ADME yang berhubungan dengan gen termasuk histamin dan oksidator diamina tembaga enzim ABP1, CYP4F12 metabolisme arachidonic acid, monooxygenase flavin FMO4, thymodylate sintase (ENOSF1/TYMS) terlibat dalam respon 5-Fluorourasil dan pembawa terlarut SLC22A10, antara lain. Selain itu, UGT1A1 ekspresi adalah terkait dengan rs2070959 (terletak di UGT1A6), yang erat ([r.sup.2] = 0,87) untuk rs8175347, SNP kausal dari UGT1A1 * 28 alel. (44) hebatnya, polimorfisme terkenal ini telah tidak telah terdeteksi oleh studi Seattle. (16) kotak plot ini eQTLs unik yang diwakili oleh satu SNP ditampilkan dalam tambahan angka S1.

Hasil (Bahasa Indonesia) 2:

Table 2 shows the 74 ADME associations (68 cis-acting and 6 trans-acting) uniquely identified in our study, which mapped to 31 different trait genes. Closer analysis showed that the corresponding SNPs had indeed been analyzed but were not significantly associated with expression in the former study. (16) These unique associations included additional SNPs for traits mentioned in Table 1 but with LD of [r.sup.2]<0.8 (for example, ARNT, several GSTs, VKORC1) and additional ADME and ADME-related genes including the histamine and diamine-oxidizing copper enzyme ABP1 , the arachidonic acid-metabolizing CYP4F12, the flavin monooxygenase FMO4, thymodylate synthase (ENOSF1/TYMS) involved in 5-fluorouracil response and the solute carrier SLC22A10, among others. Furthermore, UGT1A1 expression was associated with rs2070959 (located in UGT1A6), which is closely linked ([r.sup.2] = 0.87) to rs8175347, the causal SNP of the UGT1A1*28 allele. (44) Remarkably, this well-known polymorphism had not been detected by the Seattle study. (16) Box plots of these unique eQTLs represented by one SNP each are shown in Supplementary Figure S1.