(1) desethylhydroxychloroquine, (2)

(1) desethylhydroxychloroquine, (2) desethylchloroquine,
and (3) bisdesethylchloroquine.47 The parent
compound and metabolites are taken up by lysosomes
and concentrated in lysosome-rich tissues. Renal clearance
accounts for approximately 15%–25% of the total
clearance.53 The renal excretion of CQ, HCQ, and QE
can be enhanced with acidification of the urine.54 QE is
excreted in urine, bile, sweat, and saliva.50 Renal excretion
only accounts for approximately 11% of its clearance.
The highest tissue concentrations of QE are found
in the liver and spleen.52 Equivalent doses of these

Hasil (Bahasa Indonesia) 2:

(1) desethylhydroxychloroquine, (2) desethylchloroquine,
dan (3) bisdesethylchloroquine.47 induk
senyawa metabolit dan diambil oleh lisosom
dan terkonsentrasi di jaringan kaya lisosom. Izin ginjal
menyumbang sekitar 15% -25% dari total
clearance.53 Ekskresi ginjal CQ, HCQ, dan QE
dapat ditingkatkan dengan pengasaman dari QE urine.54 yang
diekskresikan dalam urin, empedu, keringat, dan saliva.50 ekskresi ginjal
hanya menyumbang sekitar 11% dari izin-nya.
Konsentrasi jaringan tertinggi QE ditemukan
di hati dan spleen.52 dosis Setara ini