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After oral administration, the drug is well absorbed, protein binding is relevant (96%) and the Int. J. Electrochem. Sci., Vol. 7, 2012 2532 mean elimination half-life is 12 h [2]. A review of the literature revealed that several analytical methods have been described for the determination of duloxetine in pharmaceuticals including UV spectrophotometric[3], spectrofluorometric[4], high performance thin layer chromatography [5] and Liquid chromatographic [6].
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