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Comparing Prokaryotic and Eukaryotic CellsAll cells share certain basic features: They are all bounded bya selective barrier, called theplasma membrane. Inside all cellsis a semifluid, jellylike substance calledcytosol, in whichsubcellular components are suspended. All cells containchromosomes, which carry genes in the form of DNA. And allcells haveribosomes, tiny complexes that make proteins ac-cording to instructions from the genes.A major difference between prokaryotic and eukaryotic cellsis the location of their DNA. In aeukaryotic cell, most of theDNA is in an organelle called thenucleus, which is bounded bya double membrane (see Figure 6.8, on pp. 100–101). In aprokaryotic cell, the DNA is concentrated in a region thatis not membrane-enclosed, called thenucleoid(Figure 6.5).The wordeukaryoticmeans “true nucleus” (from the Greekeu,true, andkaryon, kernel, here referring to the nucleus), andthe wordprokaryoticmeans “before nucleus” (from the Greekpro, before), reflecting the fact that prokaryotic cells evolvedbefore eukaryotic cells.The interior of either type of cell is called thecytoplasm; ineukaryotic cells, this term refers only to the region between thenucleus and the plasma membrane. Within the cytoplasm of aeukaryotic cell, suspended in cytosol, are a variety of organellesof specialized form and function. These membrane-boundedstructures are absent in prokaryotic cells. Thus, the presence orabsence of a true nucleus is just one aspect of the disparity instructural complexity between the two types of cells.Eukaryotic cells are generally much larger than prokary-otic cells (see Figure 6.2). Size is a general feature of cell struc-ture that relates to function. The logistics of carrying outcellular metabolism sets limits on cell size. At the lower limit,the smallest cells known are bacteria called mycoplasmas,which have diameters between 0.1 and 1.0 μm. These areperhaps the smallest packages with enough DNA to programmetabolism and enough enzymes and other cellular equip-ment to carry out the activities necessary for a cell to sustainitself and reproduce. Typical bacteria are 1–5 μm in diameter,about ten times the size of mycoplasmas. Eukaryotic cells aretypically 10–100 μm in diameter.Metabolic requirements also impose theoretical upper limitson the size that is practical for a single cell. At the boundary ofevery cell, theplasma membranefunctions as a selectivebarrier that allows passage of enough oxygen, nutrients, andwastes to service the entire cell(Figure 6.6). For each square mi-crometer of membrane, only a limited amount of a particular
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