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Moisture Barrier of the SkinIn order to understand the pathophysiology of IAD, it is necessary to briefly review the elements of the skin’s moisture barrier. In addition to immune related and thermoregulation functions, the skin acts as a barrier between internal and external environments. It protects the body from exposure to irritants or toxic materials in the environment, while preventing excessive loss of fluids and electrolytes from the internal environment (Gray, 2010)
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