NSAIDsNSAIDs or nonsteroidal anti-i

NSAIDs
NSAIDs or nonsteroidal anti-inflammatory
drugs are among the most
commonly used analgesics in the
world and are often used as first-line
medications for joint pain. One UK
telephone survey in 2003 reported that
50% of respondents with osteoarthritis
were taking NSAIDs.2
There is good level I evidence for
the analgesic effect of NSAIDs in
OA, and meta-analyses of short-term,
placebo-controlled randomized trials
have shown an effect size between 0.23
and 0.32 in terms of reduction in pain.2
NSAIDs, however, are associated
with more adverse effects than acetaminophen.
2,3 Gastrointestinal (GI)
discomfort occurs more frequently
and, more importantly, serious complications
such as peptic ulcers, per forations,
and bleeds are more likely to
occur.2,3 Pooled relative risk compared
to placebo is estimated at 270%.2 Risk
also increases with age, concurrent
use of other medications, and duration
of therapy.

Hasil (Bahasa Indonesia) 2:

NSAID
NSAID atau anti-inflamasi nonsteroid
obat adalah yang paling
analgesik umum digunakan di
dunia dan sering digunakan sebagai lini pertama
obat untuk nyeri sendi. Satu UK
survei telepon pada tahun 2003 melaporkan bahwa
50% dari responden dengan osteoarthritis
mengambil NSAIDs.2
Ada tingkat yang baik saya bukti untuk
efek analgesik NSAID di
OA, dan meta-analisis dari jangka pendek,
percobaan acak terkontrol plasebo
menunjukkan efek ukuran antara 0,23
dan 0,32 dalam hal pengurangan pain.2
NSAID, bagaimanapun, terkait
dengan efek samping lebih dari acetaminophen.
2,3 gastrointestinal (GI)
ketidaknyamanan terjadi lebih sering
dan, yang lebih penting, komplikasi serius
seperti tukak lambung , per forations,
dan pendarahan lebih mungkin untuk
occur.2,3 risiko relatif Pooled dibandingkan
dengan plasebo diperkirakan 270% risk 0,2
juga meningkat dengan usia, bersamaan
penggunaan obat lain, dan durasi
terapi.