Ligand binding domain of the proges

Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
The ligand binding domain of the progesterone receptor (PR): PR is a member of the nuclear receptor superfamily of ligand dependent transcription factors, mediating the biological actions of progesterone. PR functions in a variety of biological processes including development of the mammary gland, regulating cell cycle progression, protein processing, and metabolism. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. After progesterone binds to the receptor, PR forms a dimer and the complex enters the nucleus where it interacts with the hormone response element (HRE) in the promoters of progesterone responsive genes and alters their transcription. In addition, rapid actions of PR that occur independent of transcription, have also been observed in several tissues like brain, liver, mammary gland and spermatozoa. There are two natural PR isoforms called PR-A and PR-B. PR-B has an additional stretc h of 164 amino acids at the N terminus. The extra domain in PR-B performs activation functions by recruiting coactivators that could not be recruited by PR-A. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, PR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). The LBD is not only involved in binding to progesterone, but also involved in coactivator binding and dimerization.

Hasil (Bahasa Indonesia) 1:

Ligan domain mengikat reseptor progesteron, anggota reseptor nuklir hormonThe ligand binding domain of the progesterone receptor (PR): PR is a member of the nuclear receptor superfamily of ligand dependent transcription factors, mediating the biological actions of progesterone. PR functions in a variety of biological processes including development of the mammary gland, regulating cell cycle progression, protein processing, and metabolism. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. After progesterone binds to the receptor, PR forms a dimer and the complex enters the nucleus where it interacts with the hormone response element (HRE) in the promoters of progesterone responsive genes and alters their transcription. In addition, rapid actions of PR that occur independent of transcription, have also been observed in several tissues like brain, liver, mammary gland and spermatozoa. There are two natural PR isoforms called PR-A and PR-B. PR-B has an additional stretc h of 164 amino acids at the N terminus. The extra domain in PR-B performs activation functions by recruiting coactivators that could not be recruited by PR-A. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, PR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). The LBD is not only involved in binding to progesterone, but also involved in coactivator binding and dimerization.

Hasil (Bahasa Indonesia) 2:

Ligan domain dari reseptor progesteron mengikat, anggota dari hormon nuklir reseptor
Ligan mengikat domain dari reseptor progesteron (PR): PR adalah anggota dari superfamili reseptor nuklir ligan faktor transkripsi tergantung, menengahi tindakan biologis progesteron. Fungsi PR dalam berbagai proses biologi termasuk pengembangan kelenjar susu, yang mengatur progresi siklus sel, pengolahan protein, dan metabolisme. Bila tidak ada hormon yang mengikat hadir terminal karboksil menghambat transkripsi. Mengikat hormon menginduksi perubahan struktural yang menghilangkan tindakan hambat. Setelah progesteron mengikat reseptor, PR membentuk dimer dan kompleks memasuki nukleus di mana ia berinteraksi dengan elemen respon hormon (HRE) di promotor gen responsif progesteron dan mengubah transkripsi mereka. Selain itu, tindakan cepat PR yang terjadi independen dari transkripsi, juga telah diamati di beberapa jaringan seperti otak, hati, kelenjar susu dan spermatozoa. Ada dua isoform PR alami yang disebut PR-A dan PR-B. PR-B memiliki h stretc tambahan dari 164 asam amino pada ujung N. Domain ekstra dalam PR-B melakukan fungsi aktivasi dengan merekrut coactivators yang tidak bisa direkrut oleh PR-A. Seperti anggota lain dari reseptor nuklir (NR) superfamili dari faktor transkripsi ligand-diaktifkan, PR memiliki pusat juga dilestarikan DNA mengikat domain (DBD), domain N-terminal variabel, engsel fleksibel dan ligan C-terminal domain mengikat ( LBD). The LBD tidak hanya terlibat dalam mengikat progesteron, tetapi juga terlibat dalam koaktivator mengikat dan dimerisasi.