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DiureticsMany authorities recognize the value of diuretics as first-lineagents for the majority of patients with hypertension.Extensive experience with using diuretics, as well as theirpractical attributes (acquisition cost and availability as combinationagents), make thiazide-type diuretics a seeminglyattractive selection as first-line agents. The endorsement byJNC 7 as an initial drug therapy selection for stage 1 and stage2 hypertensive patients without compelling indications isbased on a litany of placebo-controlled studies, and in nosmall way, on the results of active controlled outcome studiessuch as ALLthat
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