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In normal adult pig kidneys, E-cadherin expression was observed from the outer cortex to the inner medulla. The area containing E-cadherin was proportionately greater in the medulla than in the cortex (Figs. 1A~C). E-cadherin immunostaining was present in the basolateral plasma membrane domain of the tubular epithelial cells (Figs. 1A~C, insets) as previously described [3,12,21,25]. Expression of this protein was not detected in glomeruli or blood vessels. Double immunolabeling with aquaporin 1 revealed that E-cadherin was not expressed in the proximal tubule or descending thin limb but high levels were present in the distal tubule of the pig kidney
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