cationic/anionic exchangers and so

cationic/anionic exchangers and so they may
undergo in exchange with basic drug in
solution. Release rate of the drug decreased
with enhancement of the matrix
concentrations.
F4 showed the lowest drug release rate,
and F7 showed the fastest between the other
formulas. The drug release showed the
exponential/parabolic curve showed by the β
(shape parameter of Weibull’s equation)

Hasil (Bahasa Indonesia) 1:

cationic/anionic exchangers and so they mayundergo in exchange with basic drug insolution. Release rate of the drug decreasedwith enhancement of the matrixconcentrations.F4 showed the lowest drug release rate,and F7 showed the fastest between the otherformulas. The drug release showed theexponential/parabolic curve showed by the β(shape parameter of Weibull’s equation) <1,there are indicated that the initial release withhigher slope in the initial. The drug releaseusing 2 release models were initial burst releaseoccurred at 0 until 60min and maintenancerelease that occurred at 60-360 min.Dissolution profile all formulas were comparedwith dissolution efficiency until 360 minutes(DE360), initial burst release and maintenancerelease. The result showed significant differentwith value of DE360 (p<0.05), initial burstrelease (p<0.05) and maintenance release(p<0.05). Release rate was determined by theprofile pharmacokinetics approach of captoprilwith the rate of maintenance release more than0.02mg/min and approach the steady stateconcentration (0.05mg/min) and the lowestinitial burst release rate. Montmorillonit 40%has been required the lowest of initial burstrelease rate and the expected ofpharmacokinetics profile approach (steadystate)

Hasil (Bahasa Indonesia) 2:

kationik penukar / anionik dan sehingga mereka dapat
menjalani dalam pertukaran dengan obat dasar dalam
solusi. Laju pelepasan obat menurun
dengan peningkatan matriks
konsentrasi.
F4 menunjukkan tingkat pelepasan obat termurah,
dan F7 menunjukkan tercepat antara lain
formula. Pelepasan obat menunjukkan
eksponensial / kurva parabola menunjukkan dengan β
(bentuk parameter persamaan Weibull ini) <1,
ada menunjukkan bahwa rilis awal dengan
kemiringan yang lebih tinggi di awal. Pelepasan obat
menggunakan 2 model rilis yang rilis ledakan awal
terjadi pada 0 sampai 60menit dan pemeliharaan
rilis yang terjadi di 60-360 menit.
Profil Pembubaran semua formula dibandingkan
dengan efisiensi disolusi sampai 360 menit
(DE360), rilis meledak awal dan pemeliharaan
rilis. Hasil penelitian menunjukkan signifikan berbeda
dengan nilai DE360 (p <0,05), awal meledak
rilis (p <0,05) dan rilis pemeliharaan
(p <0,05). Laju pelepasan ditentukan oleh
pendekatan farmakokinetik profil kaptopril
dengan laju pelepasan perawatan lebih dari
0.02mg / min dan mendekati steady state
konsentrasi (0.05mg / min) dan terendah
awal laju pelepasan meledak. Montmorillonit 40%
telah diperlukan terendah dari ledakan awal
laju pelepasan dan diharapkan dari
pendekatan profil farmakokinetik (steady
state)