Peripheral Artery DiseasePAD is ano

Peripheral Artery Disease
PAD is another important vascular
complication of T1DM (Supplementary
Table 2). There are several components
of PAD, including occult disease,
assessed by ankle-brachial index, ex-
tremity arterial calcification, and lower-
extremity nontraumatic amputation. The
data available on PAD focus on amputa-
tion. The rate of nontraumatic amputation
in T1DM is high, occurring at 0.4–7.2% per
year (28). By 65 years of age, the cumu-
lative probability of lower-extremity am-
putation in a Swedish administrative
database was 11% for women with
T1DM and 20.7% for men (10). In this
Swedish population, the rate of lower-
extremity amputation among those with
T1DM was nearly 86-fold that of the gen-
eral population. Calcification of the ex-
tremity arteries was reported in 4.6% of
the EDC cohort, more commonly in men,
and in individuals .30 years of age (29).
Predictors of all types of PAD include in-
creasing age, male sex, history of foot le-
sions or ulcers, diastolic BP, low-density
lipoprotein cholesterol (LDL-C), glycosy-
lated hemoglobin (HbA1c), DM duration,
hypertension, albumin excretion rate, glo-
merular filtration rate (GFR), smoking sta-
tus, and retinopathy (10,28,30,31). In a
meta-analysis of 5 studies of T1DM pa-
tients, with each 1% increase in HbA1c
the risk of PAD increased by 18% (32). In-
terestingly, aggressive glycemic control to
lower the HbA1c did not appear to reduce
rates of peripheral arterial occlusion in
the DCCT/EDIC study but did reduce the
incidence of peripheral arterial calcifica-
tion (31).

Hasil (Bahasa Indonesia) 1:

Penyakit arteri periferPAD adalah penting lainnya vaskularkomplikasi dari T1DM (tambahanTabel 2). Ada beberapa komponenpad, termasuk penyakit okultisme,dinilai oleh pergelangan kaki-brakialis indeks, ex-tremity arteri calcification, dan lebih rendah-amputasi ekstremitas nontraumatic. Thedata yang tersedia pada PAD fokus pada amputa-tion. Tingkat nontraumatic amputasidalam T1DM tinggi, terjadi pada 0.4-7,2% pertahun (28). Usia, cumu - 65 tahunam lative probabilitas rendah-ekstremitas-putation di Swedia administrasidatabase adalah 11% untuk wanita denganT1DM dan 20.7% untuk laki-laki (10). Dalam hal iniPenduduk Swedia, tingkat rendah-amputasi ekstremitas antara mereka denganT1DM adalah hampir 86-fold yang menye -memeriksa populasi. Calcification ex-arteri tremity dilaporkan dalam 4.6%kohort EDC, lebih sering pada pria,dan dalam individu 30 tahun (29).Prediksi dari semua jenis pad termasuk di-untuk memperkuat usia, seks laki-laki, sejarah kaki le-kandungan atau ulkus, BP diastolik, low densitykolesterol lipoprotein (LDL-C), glycosy-laranangan dan saksi hemoglobin (HbA1c), durasi DM,hipertensi, laju ekskresi albumin, glo-merular filtration tingkat (GFR), Merokok sta-tus, dan retinopati (10,28,30,31). Dalammeta-analisis studi 5 T1DM pa-tients, dengan masing-masing 1% peningkatan HbA1crisiko PAD meningkat sebesar 18% (32). Di-terestingly, agresif glycemic control untuklebih rendah HbA1c tidak muncul untuk mengurangitingkat oklusi arteri perifer dalamDCCT EDIC studi tetapi melakukan mengurangiinsiden arteri perifer calcifica-tion (31).