AbstractObjectives: To examine the

Abstract
Objectives:

To examine the associations of antibiotic exposures during the first 2 years of life and the development of body mass over the first 7 years of life.
Design:

Longitudinal birth cohort study.
Subjects:

A total of 11 532 children born at 2500 g in the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based study of children born in Avon, UK in 1991–1992.
Measurements:

Exposures to antibiotics during three different early-life time windows (

Hasil (Bahasa Indonesia) 1:

AbstrakTujuan: Untuk memeriksa Asosiasi eksposur antibiotik selama 2 tahun pertama kehidupan dan pengembangan massa tubuh selama 7 tahun pertama kehidupan.Desain: Studi kohort longitudinal kelahiran.Subjek: Total 11 532 anak-anak yang lahir di 2500 g di Avon Longitudinal belajar dari orang tua dan anak-anak (ALSPAC), sebuah studi berdasarkan populasi anak-anak yang lahir di Avon, Inggris tahun 1991-1992.Pengukuran: Eksposur terhadap antibiotik selama tiga jendela kehidupan waktu yang berbeda (< 6 bulan, 6-14 bulan, bulan 15-23), dan indeks tubuh massa di waktu lima poin (6 minggu, bulan 10, 20 bulan, 38 bulan dan 7 tahun).Hasil: Antibiotik paparan selama jendela waktu awal (< 6 bulan) secara konsisten dikaitkan dengan tubuh meningkat massa (+0.105 dan +0.083 s.d. unit, kenaikan berat badan-untuk-length Z-Skor 10 dan 20 bulan, P < 0.001 dan P = 0.001, masing-masing; massa tubuh index (BMI) Z-Skor di bulan + 0.067 38 s.d. unit, P = 0.009; kelebihan berat badan atau 1,22 pada bulan 38, P = 0.029) di multivariable, model efek dicampur mengendalikan obesitas sosial dan perilaku yang diketahui faktor risiko. Paparan dari 6 14 bulan yang menunjukkan tidak ada kaitan dengan massa tubuh, sementara paparan dari 15 23 bulan bermakna dikaitkan dengan peningkatan Skor-BMI Z di 7 tahun (+0.049 s.d. unit, P = 0,050). Eksposur untuk obat bebas-antibiotik tidak dikaitkan dengan tubuh massa.Kesimpulan: Paparan terhadap antibiotik selama 6 bulan pertama kehidupan dikaitkan dengan peningkatan yang konsisten dalam massa tubuh dari 10 bulan 38. Eksposur kemudian di masa kanak-kanak (6 – 14 bulan, bulan 15-23) tidak konsisten terkait dengan tubuh meningkat massa. Meskipun efek eksposur awal sederhana pada tingkat individu, mereka bisa memiliki konsekuensi besar bagi kesehatan penduduk. Mengingat prevalensi eksposur antibiotik pada bayi, dan dalam terang keprihatinan tentang obesitas, lebih lanjut studi yang diperlukan untuk mengisolasi efek dan menentukan hidup-kursus implikasi bagi risiko massa dan kardiovaskular tubuh.

Hasil (Bahasa Indonesia) 2:

Abstract
Objectives:

To examine the associations of antibiotic exposures during the first 2 years of life and the development of body mass over the first 7 years of life.
Design:

Longitudinal birth cohort study.
Subjects:

A total of 11 532 children born at 2500 g in the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based study of children born in Avon, UK in 1991–1992.
Measurements:

Exposures to antibiotics during three different early-life time windows (<6 months, 6–14 months, 15–23 months), and indices of body mass at five time points (6 weeks, 10 months, 20 months, 38 months and 7 years).
Results:

Antibiotic exposure during the earliest time window (<6 months) was consistently associated with increased body mass (+0.105 and +0.083 s.d. unit, increase in weight-for-length Z-scores at 10 and 20 months, P<0.001 and P=0.001, respectively; body mass index (BMI) Z-score at 38 months +0.067 s.d. units, P=0.009; overweight OR 1.22 at 38 months, P=0.029) in multivariable, mixed-effect models controlling for known social and behavioral obesity risk factors. Exposure from 6 to 14 months showed no association with body mass, while exposure from 15 to 23 months was significantly associated with increased BMI Z-score at 7 years (+0.049 s.d. units, P=0.050). Exposures to non-antibiotic medications were not associated with body mass.
Conclusions:

Exposure to antibiotics during the first 6 months of life is associated with consistent increases in body mass from 10 to 38 months. Exposures later in infancy (6–14 months, 15–23 months) are not consistently associated with increased body mass. Although effects of early exposures are modest at the individual level, they could have substantial consequences for population health. Given the prevalence of antibiotic exposures in infants, and in light of the growing concerns about childhood obesity, further studies are needed to isolate effects and define life-course implications for body mass and cardiovascular risks.