A B S T R A C TMicrobial transforma

A B S T R A C T
Microbial transformation of bavachin (1), one of the major bioactive components of Psoralea corylifolia L.,
was performed by using Absidia coerulea. Three oxidized metabolites were obtained in the
biotransformation of 1, and their structures were elucidated as bavachinone A (2), (2S)-40
-hydroxy-
6,7-[(R)-2-(1-hydroxy-1-methylethyl)-2,3-dihydrofurano]flavanone (3), and (2S)-40
,7-dihydroxy-6-(2,3-
dihydroxy-3-methylbutyl)flavanone (4) based on the spectroscopic analyses. Among them, metabolites 3
and 4 were new compounds. The biotransformation study suggested that 1 was fully oxidized to its
metabolites within 5 days. Thus, biotransformation by A. coerulea can be used as a promising method for
oxidation of bavachin.

Hasil (Bahasa Indonesia) 1:

B S T R C TMikroba transformasi bavachin (1), salah satu komponen bioaktif utama pedunculata corylifolia L.,ini dilakukan dengan menggunakan Absidia coerulea. Tiga teroksidasi metabolit mereka Diperoleh daribiotransformasi 1, dan struktur mereka yang dipahami sebagai bavachinone A (2), (2S) -40-hidroksi-6,7-[(R)-2-(1-hydroxy-1-methylethyl)-2,3-dihydrofurano]flavanone (3), dan (2S) -40, 7-dihydroxy - 6-(2,3-dihydroxy-3-methylbutyl) flavanone (4) berdasarkan analisis bintang. Di antara mereka, metabolit 3dan 4 senyawa baru. Studi biotransformasi menyarankan bahwa 1 lengkap teroksidasi untuk nyametabolit dalam 5 hari. Oleh karena itu, biotransformasi oleh A. coerulea dapat digunakan sebagai metode yang menjanjikan untukoksidasi dari bavachin.