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Synergistic interactions between mixtures of antioxidants can be explained as follows: 1. Regeneration of the more effective antioxidant in the system by other less effective antioxidants or oxidation retarders, 2. Metal chelation by one antioxidant sparing a chain breaking antioxidant, 3. Interaction of antioxidants with different solubility (Becker et al. 2004). A combination of these different mechanisms is a possible explanation of synergy between TOH or QC and polyphenols, thus protecting each other against reactive oxygen species (yin et al. 2012). On the other hand, AA did not show synergistic effects in combination with PPE or PSE in liposomes but rather antagonistic effects. An antagonistic effect was also shown between thyme or rosemary extracts and AA in liposomes, which was explained by kinetic factors (Nieto, Huvaere and Skibsted 2011).
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