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This study examined the effects of combining innovative approaches in teaching general biology on the development ofstudents’ science process skills. Two intact classes of college non-science freshmen from a government-managed higherlearning institution in the Philippines were compared. An instructional package based on standard tertiary level GeneralBiology course employing multiple representations to be delivered through collaborative teaching and learning approachwas designed and compared against the traditional approach to teaching. Quantitative data were obtained from the studentsscores in Prior Science Knowledge test and Science Process Skills rubric. Qualitative data were obtained from the analysisof students’ focus group discussion. The t -test was done to determine the difference in the observed mean scores at = 0.05level of significance. Results showed significantly higher scores in the science process skills of students exposed to themultiple representations and collaborative learning approach. Prior science knowledge was found to have no significantcorrelation with science process skills. Students’ science process skills were also found to differ across gender.
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