In conclusion, as the result of tha

In conclusion, as the result of that there were notable heterogeneities among the included studies for the comparisons of D vs I and DD vs (DI+II) (when significant statistical heterogeneity was observed among the included studies, the final results would come from those of the random effects models), the final results for the analysis of the association of ACE I/D gene polymorphism with SRNS susceptibility in Asian children were as follow: D: OR = 1.60, P = 0.26; DD: OR = 1.90, P = 0.38; II: OR = 0.51, P = 0.02 (Table 4).

Sensitivity analysis

The gene distribution of control group in the included study was not in HWE, which might be an important reason to cause heterogeneity to our investigation. In this meta-analysis, sensitivity analysis was performed. The genotype distributions of the control population in one study [8] didn't conform to HWE and this investigation was excluded from our study. Finally, four studies [4], [26], [27], [28] were recruited into our sensitivity analysis.

In the sensitivity analysis, the association of D allele or DD homozygous with SRNS susceptibility in Asian children wasn't observed when fixed effects method or random effects method was used (Table 4). Combination the results from sensitivity analysis with those in non-sensitivity analysis mentioned above, we might draw a stable conclusion that D allele and DD homozygous were not associated with SRNS susceptibility in Asian children.

The II genotype seemed not to play a protective role against SRNS risk in our sensitivity analysis when fixed effects method or random effects method was performed (Table 4). It was inconsistent with that in non-sensitivity analysis mentioned above, and the conclusion for II allele in our study was instable.

Hasil (Bahasa Indonesia) 2:

Kesimpulannya, sebagai hasil dari yang ada heterogeneities penting antara studi disertakan untuk perbandingan D vs I dan DD vs (DI + II) (ketika heterogenitas statistik signifikan diamati antara studi disertakan, hasil akhir akan datang dari orang-orang efek random model), hasil akhir untuk analisis asosiasi ACE I polimorfisme / gen D dengan SRNS kerentanan pada anak-anak Asia adalah sebagai berikut: D: OR = 1,60, P = 0,26; DD: OR = 1,90, P = 0,38; II:. OR = 0,51, P = 0,02 (Tabel 4) Analisis sensitivitas Distribusi gen dari kelompok kontrol dalam penelitian termasuk tidak di HWE, yang mungkin menjadi alasan penting untuk menyebabkan heterogenitas penyelidikan kami. Dalam meta-analisis ini, analisis sensitivitas dilakukan. Distribusi genotipe dari populasi kontrol dalam satu studi [8] tidak sesuai dengan HWE dan investigasi ini dikeluarkan dari penelitian kami. Akhirnya, empat penelitian [4], [26], [27], [28] direkrut ke dalam analisis sensitivitas kami. Dalam analisis sensitivitas, asosiasi D alel atau DD homozigot dengan SRNS kerentanan pada anak-anak Asia tidak diamati ketika Metode efek tetap atau metode efek random digunakan (Tabel 4). Kombinasi hasil dari analisis sensitivitas dengan orang-orang dalam analisis non-sensitivitas yang disebutkan di atas, kita mungkin menarik kesimpulan yang stabil yang D alel dan DD homozigot tidak terkait dengan SRNS kerentanan pada anak-anak Asia. The genotipe II tampaknya tidak memainkan peran protektif terhadap SRNS risiko dalam analisis sensitivitas kami ketika metode efek tetap atau metode efek random dilakukan (Tabel 4). Itu tidak konsisten dengan itu dalam analisis non-sensitivitas yang disebutkan di atas, dan kesimpulan untuk II alel dalam penelitian kami adalah stabil.