AetiologyThe Nipah virus is closely

Aetiology
The Nipah virus is closely related to Hendra virus (HeV) and Cedar
virus [12,13]. They are the three recognized species members of the
genus
Henipavirus
, a new class of virus in the
Paramyxoviridae
family.
Among Paramyxoviruses, henipaviruses are characterized by
a wider host range and a larger genome [12], when compared to
the other members of the family, such as measles virus and canine
distemper virus, showing generally a narrow host range and genetically
stable with an almost uniform genome size shared by all members of
Paramyxovirinae
[9].
Nipah is an envelope, negative-sense, single-stranded RNA virus,
with a genome sequence size of about 18,000 nucleotides. NiV genome
organization comprises six major genes present in all
Paramyxovirus:
RNA polymerase and nucleocapsid genes (N, P and L); envelope
membrane protein genes (F and G); and matrix protein (M). The
attachment (G) glycoprotein which binds the viral receptor, and the
fusion (F) glycoprotein which drives virus-host cell membrane fusion,
are the two membrane-anchored envelope glycoproteins responsible
for host cell infection by NiV [9]. Virions are pleomorphic, ranging in
size from 40 to 600 nm in diameter [14].

Hasil (Bahasa Indonesia) 1:

Pada etiologiNipah virus terkait erat dengan virus Hendra (HeV) dan Cedar virus [12,13]. Mereka adalah anggota spesies tiga genus Henipavirus, kelas baru virus di Paramyxoviridae Keluarga.Antara Paramyxoviruses, henipaviruses yang ditandai dengan tuan rumah yang lebih luas dan lebih besar genom [12], jika dibandingkan dengan anggota lain dari keluarga, seperti virus campak dan anjing dinding virus, menampilkan umumnya berbagai sempit host dan genetika stabil dengan ukuran hampir seragam genom bersama oleh semua anggota Paramyxovirinae [9].Nipah adalah amplop, negatif-rasa, tunggal virus RNA, dengan urutan genom ukuran sekitar 18.000 nukleotida. NiV genom organisasi terdiri dari enam gen utama hadir dalam segenap Paramyxovirus: RNA polimerase dan nukleokapsid sebuah gen (N, P & L); amplop gen protein membran (F dan G); dan matriks protein (M). The Lampiran (G) glikoprotein yang mengikat reseptor virus, dan fusi (F) glikoprotein yang mendorong virus-host membran sel fusion, Apakah dua membran-berlabuh amplop glikoprotein bertanggung jawab untuk host sel infeksi oleh NiV [9]. Virion pleomorphic, mulai ukuran dari 40 sampai 600 nm diameter [14].