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The bone marrow is hypercellular and types I and II myeloblasts make up from 30-83% of the promyelocytes to mature segmented cells. The monocytic component is less than 20%, differentiating M2 from M4. Basophils in some patient (M2 baso) was increased. Eosinophils and their precursors may be abundant, and in some cases accounts for up to 15% of myelogram (Berger and Flandrin, 1984). The characteristic that distinguishes AML-M2 from AML-M1 is the presence of maturation at orbeyond the promyelocyte stage. Abnormal neutrophil maturation appears to be an integral part of AML-M2 with t(8;21) translocation. The neutrophils may show many abnormalnuclear segmentations and Auer rods.
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