A few methods in literature were re

A few methods in literature were reported for the determination of duloxetine in biological fluids [7-9]. Ion-selective electrodes have been increasingly used for quantitative measurement of drugs. Potentiometric methods based on this technique are simple, rapid, low cost, low detection limit, good accuracy, wide concentration range, applicability to coloured and turbid solutions and offer enough selectivity towards the drugs in the presence of various pharmaceutical excipients [10, 11].The present investigation describes a simple, rapid and selective duloxetine membrane electrode. The electrode is based on the incorporation of duloxetinesilicomolybdate ‎ [DLX-SMA] ion pair in poly (vinyl chloride) (PVC) membranes plasticized with dioctylphthalate (DOP). The prepared electrode has been used for the determination of the duloxetine
pharmaceutical formulations without any prior separation and humane urine sample. The effects of membranes compositions, response time, selectivity and other factors have been investigated on
electrodes performance are described

Hasil (Bahasa Indonesia) 2:

Beberapa metode dalam literatur dilaporkan untuk penentuan duloxetine dalam cairan biologis [7-9]. Elektroda selektif ion telah semakin digunakan untuk pengukuran kuantitatif obat. Metode potensiometri berdasarkan teknik ini adalah sederhana, cepat, biaya rendah, batas deteksi rendah, akurasi yang baik, rentang konsentrasi yang luas, penerapan untuk berwarna dan keruh solusi dan menawarkan cukup selektivitas terhadap obat di hadapan berbagai eksipien farmasi [10, 11] .suatu penyelidikan ini menggambarkan sederhana, cepat dan selektif duloxetine membran elektroda. Elektroda ini didasarkan pada penggabungan duloxetinesilicomolybdate [DLX-SMA] pasangan ion di poli (vinil klorida) (PVC) membran plasticized dengan dioctylphthalate (DOP). Elektroda siap telah digunakan untuk penentuan duloxetine
formulasi farmasi tanpa pemisahan sebelumnya dan sampel urin manusiawi. Efek komposisi membran, waktu respon, selektivitas dan faktor lainnya telah diteliti pada
kinerja elektroda dijelaskan